1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Glutathione Peroxidase

Glutathione Peroxidase

Glutathione Peroxidase (GPx) is the general name of an enzyme family with peroxidase activity whose main biological role is to protect the organism from oxidative damage. Glutathione peroxidase functions to reduce lipid hydroperoxides to their corresponding alcohols and to reduce free hydrogen peroxide to water.

Glutathione peroxidase plays a role in the development of celiac disease. Several isozymes glutathione peroxidase are encoded by different genes, which vary in cellular location and substrate specificity. Glutathione peroxidase 1 (GPx1) is the most abundant version, existing in the cytoplasm of nearly all mammalian tissues, whose preferred substrate is hydrogen peroxide. Glutathione peroxidase 4 (GPx4) has a high preference for lipid hydroperoxides; it is expressed in almost all the mammalian cells, though at much lower levels. Glutathione peroxidase 2 is an intestinal and extracellular enzyme, while glutathione peroxidase 3 is extracellular, especially abundant in plasma. So far, eight different isoforms of glutathione peroxidase (GPx1-8) have been identified in humans.

Glutathione Peroxidase 相关产品 (10):

Cat. No. Product Name Effect Purity
  • HY-100218A
    (1S,3R)-RSL3 Inhibitor 99.87%
    (1S,3R)-RSL3 是一种谷胱甘肽过氧化物酶 4 (GPX4) 的抑制剂,可降低 GPX4 的表达,诱导头颈部癌细胞的肥大性死亡。在 HN3 耐受细胞中,可增加 p62 和 Nrf2 的蛋白水平,使 Keap1 灭活。
  • HY-111341
    AZD5904 Inhibitor >98.0%
    AZD5904 是一种有效且不可逆的人髓过氧化物酶 (MPO) 抑制剂,其 IC50 值为 140 nM,在小鼠和大鼠中也具有相似的效力。
  • HY-17646
    Verdiperstat Inhibitor 99.84%
    Verdiperstat (AZD3241) 是一种选择性的、不可逆的、可口服的髓过氧化物酶 (myeloperoxidase) 抑制剂,IC50 值为 630 nM,可用于大脑神经退行性疾病研究。
  • HY-100873
    PF-1355 Inhibitor 99.48%
    PF-1355 是一种有效的 MPO 抑制剂,用于血管炎的治疗。
  • HY-19321
    PF-06282999 Inhibitor 99.41%
    PF-06282999 是一种有效的,选择性的髓过氧物酶 (myeloperoxidase) 抑制剂,用于治疗心血管疾病。
  • HY-100003
    ML-210 Inhibitor 98.64%
    ML-210 是硝基异恶唑系列中最有效的化合物,一种通过结合硒代半胱氨酸残基,有效的、选择性的 GPX4 共价抑制剂。ML-210 对于BJeLR (HRASV12),BJeH-LT ( 无 HRASV12),DRD 细胞系的 IC50 分别为 71 nM,272 nM 和 107 nM。
  • HY-135318
    NBDHEX Inhibitor
    NBDHEX 是一种有效的谷胱甘肽 S-转移酶 P1-1 (GSTP1-1) 抑制剂。 NBDHEX 诱导肿瘤细胞凋亡。NBDHEX 通过抑制 GST 的催化活性,避免抑制剂被特异性泵从细胞中排出,以及破坏 GSTP1-1 和关键信号传导因子之间的相互作用,从而起到抗癌的作用。NBDHEX 也可以作为晚期自噬抑制剂。
  • HY-N4288
    4-Methylesculetin Inhibitor 98.11%
    4-Methylesculetin 是一种可口服的天然香豆素衍生物,具有有效的抗氧化、抗炎活性。4-Methylesculetin 可抑制 myeloperoxidase 的活性,降低 IL-6 的水平
  • HY-111354
    Tinoridine hydrochloride Activator 98.07%
    Tinoridine hydrochloride是一种非甾体抗炎药,也具有强效的自由基清除和抗过氧化物活性。
  • HY-115486
    MPO-IN-28 Inhibitor 98.10%
    MPO-IN-28 (Compound 28) 是一种髓过氧化物酶 (MPO) 抑制剂,IC50 为 44 nM。
Isoform Specific Products

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