1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Glutathione Peroxidase

Glutathione Peroxidase (谷胱甘肽过氧化物酶)

Glutathione Peroxidase (GPx) is the general name of an enzyme family with peroxidase activity whose main biological role is to protect the organism from oxidative damage. Glutathione peroxidase functions to reduce lipid hydroperoxides to their corresponding alcohols and to reduce free hydrogen peroxide to water.

Glutathione peroxidase plays a role in the development of celiac disease. Several isozymes glutathione peroxidase are encoded by different genes, which vary in cellular location and substrate specificity. Glutathione peroxidase 1 (GPx1) is the most abundant version, existing in the cytoplasm of nearly all mammalian tissues, whose preferred substrate is hydrogen peroxide. Glutathione peroxidase 4 (GPx4) has a high preference for lipid hydroperoxides; it is expressed in almost all the mammalian cells, though at much lower levels. Glutathione peroxidase 2 is an intestinal and extracellular enzyme, while glutathione peroxidase 3 is extracellular, especially abundant in plasma. So far, eight different isoforms of glutathione peroxidase (GPx1-8) have been identified in humans.

Glutathione Peroxidase 相关产品 (6):

Cat. No. Product Name Effect Purity
  • HY-100218A
    RSL3 Inhibitor 99.95%
    RSL3 ((1S,3R)-RSL3) 是一种谷胱甘肽过氧化物酶 4 (GPX4) 的抑制剂 (ferroptosis 激动剂),可降低 GPX4 的表达,诱导头颈部癌细胞的肥大性死亡。在 HN3 耐受细胞中,可增加 p62 和 Nrf2 的蛋白水平,使 Keap1 灭活。
  • HY-100003
    ML-210 Inhibitor 99.92%
    ML-210 是一种选择性,共价的谷胱甘肽过氧化物酶 4 (GPX4) 抑制剂,EC50 为 30 nM。ML-210 结合 GPX4 硒代半胱氨酸残基。ML210 具有抗癌活性。
  • HY-125039
    N-Acetyl lysyltyrosylcysteine amide Inhibitor 99.81%
    N-Acetyl lysyltyrosylcysteine amide 是一种有效的,可逆的,特异性且无毒的髓过氧化物酶 (MPO) 三肽抑制剂。N-Acetyl lysyltyrosylcysteine amide 在体内可有效抑制 MPO 产生有毒氧化剂。N-Acetyl lysyltyrosylcysteine amide 减轻中风后大脑的神经元损伤,并保留脑组织和神经功能。N-Acetyl lysyltyrosylcysteine amide 抑制MPO依赖性次氯酸 (HOCl) 的生成,蛋白质硝化和 LDL 氧化。
  • HY-111354
    Tinoridine hydrochloride Activator ≥98.0%
    Tinoridine hydrochloride是一种非甾体抗炎药,也具有强效的自由基清除和抗过氧化物活性。
  • HY-N4288
    4-Methylesculetin Inhibitor 98.32%
    4-Methylesculetin 是一种可口服的天然香豆素衍生物,具有有效的抗氧化、抗炎活性。4-Methylesculetin 可抑制 myeloperoxidase 的活性,降低 IL-6 的水平
  • HY-115486
    MPO-IN-28 Inhibitor 98.10%
    MPO-IN-28 (Compound 28) 是一种髓过氧化物酶 (MPO) 抑制剂,IC50 为 44 nM。
Isoform Specific Products

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