1. Signaling Pathways
  2. Immunology/Inflammation
  3. IRAK

IRAK (白细胞介素受体相关激酶)

Interleukin-1 receptor-associated kinases (IRAKs), are serine/threonine kinases, play critical roles in initiating innate immune responses against foreign pathogens and other types of dangers through their role in Toll-like receptor (TLR) and interleukin 1 receptor (IL-1R) mediated signaling pathways. The four different IRAK-like molecules have been identified: two active kinases, IRAK-1 and IRAK-4, and two inactive kinases, IRAK-2 and IRAK-M. All IRAKs mediate activation of nuclear factor-kappaB (NF-κB) and mitogen-activated protein kinase (MAPK) pathways.

Toll-like receptors transduce their signals through the adaptor molecule MyD88 and members of the IL-1R-associated kinase family (IRAK-1, 2, M and 4). IRAK-1 and IRAK-2, known to form Myddosomes with MyD88-IRAK-4, mediate TLR7-induced TAK1-dependent NF-κB activation. IRAK-M is known to function as a negative regulator that prevents the dissociation of IRAKs from MyD88, thereby inhibiting downstream signalling.

IRAK 相关产品 (10):

目录号 产品名 作用方式 纯度
  • HY-N0039
    Ginsenoside Rb1 Inhibitor ≥98.0%
    Ginsenoside Rb1 是中药 Panax ginseng 的成分。Ginsenoside 抑制 Na+, K+-ATPase 活性,IC50 为 6.3±1.0 μM。Ginsenoside Rb1 也抑制 IRAK-1 激活及 NF-κB p65 的磷酸化。
  • HY-111101
    AZ1495 Inhibitor 99.83%
    AZ1495 (compound 28) 是具有口服活性的,白介素-1受体相关激酶 4 (IRAK4) 的抑制剂,其对 IRAK4 和 IRAK1 的 IC50 值分别为 5 nM 和 23 nM。可用于突变型 MYD88L265P 弥漫性 B 细胞淋巴瘤 (DLBCL) 的研究。
  • HY-114181
    IRAK4-IN-4 Inhibitor 99.72%
    IRAK4-IN-4 是一种白介素-1 受体相关激酶 (IRAK4) 抑制剂,IC50 为 2.8 nM。详细信息请参考专利文献 CN107163044A 中的化合物 15。IRAK4-IN-4 还抑制环 GMP-AM 合酶 (cGAS),IC50 为 2.1 nM。
  • HY-13275
    IRAK inhibitor 1 Inhibitor ≥99.0%
    IRAK inhibitor 1 是一种有效的 IRAK-4 抑制剂,IC50 为 216 nM,微弱抑制 JNK-1 和 JNK-2,IC50 分别为 3.801 μM 和 >10 μM。
  • HY-13276
    IRAK inhibitor 2 Inhibitor 98.87%
    IRAK inhibitor 2是白细胞介素-1受体相关激酶4(IRAK-4)抑制剂。
  • HY-18992
    AS2444697 Inhibitor
    AS2444697 是一种具有口服活性的 IRAK-4 抑制剂,IC50 为 21 nM。 AS2444697 有效抑制人和大鼠 IRAK-4 活性。AS2444697 通过抗炎作用表现出肾脏保护作用。
  • HY-13280
    IRAK inhibitor 6 Inhibitor 99.75%
    IRAK inhibitor 6 是一种有效的白细胞介素-1受体相关激酶-4 (interleukin-1 receptor associated kinase 4) 的抑制剂,IC50 值为 160 nM。
  • HY-13277
    IRAK inhibitor 3 Modulator 98.17%
    IRAK inhibitor 3 是一种白细胞介素-1受体相关激酶 (IRAK) 调节剂,详细信息请参考专利 WO 2008030579 A2。
  • HY-130253
    IRAK4-IN-6 Inhibitor 99.92%
    IRAK4-IN-6 是一种口服高效、选择性 IRAK 抑制剂,IC50 为 4 nM,靶向 MyD88 L265P 突变型弥漫性大 B 细胞淋巴瘤。
  • HY-13278A
    IRAK inhibitor 4 trans Inhibitor 99.09%
    IRAK inhibitor 4 (trans)是IRAK inhibitor 4的trans形式,IRAK inhibitor 4是IRAK4的有效抑制剂。
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