2. MAPK/ERK Pathway
  3. MAP3K p38 MAPK MAPKAPK2 (MK2)
  4. Tpl2 Kinase Inhibitor 1 hydrochloride

Tpl2 Kinase Inhibitor 1 hydrochloride 

目录号: HY-12358A
产品使用指南 技术支持

Tpl2 Kinase Inhibitor 1 hydrochloride 是一种选择性 Tpl2 抑制剂 (IC50=50 nM)。Tpl2 包括 COT 激酶和 MAP3K8，Tpl2 Kinase Inhibitor 1 hydrochloride 可用于炎症反应和某些癌症的研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Tpl2 Kinase Inhibitor 1 hydrochloride

Tpl2 Kinase Inhibitor 1 hydrochloride Chemical Structure

CAS No. : 2934185-09-6

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Tpl2 Kinase Inhibitor 1 hydrochloride 的其他形式现货产品:

Customer Review

Other Forms of Tpl2 Kinase Inhibitor 1 hydrochloride:

Tpl2 Kinase Inhibitor 1 hydrochloride 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 MAP3K 亚型特异性产品:

查看所有亚型
MAP3K7/TAK1 MAP3K8/COT/Tpl2 MAP3K6/ASK2 MAP3K5/ASK1

查看 p38 MAPK 亚型特异性产品:

查看所有亚型
p38 MAPK p38α p38β MAPK13 p38δ p38γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tpl2 Kinase Inhibitor 1 hydrochloride is a 3-pyridylmethylamino analog, and is a selective Tpl2 inhibitor (IC50=50 nM). Tpl2 consists of COT kinase and MAP3K8. Tpl2 Kinase Inhibitor 1 hydrochloride plays an important role in the regulation of the inflammatory response and the progression of some cancers[1][2].

IC50 & Target[1]

MAP3K8/COT/Tpl2

 

p38

180 μM (IC50)

MK2

110 μM (IC50)

体外研究
(In Vitro)

Tpl2 (Cot/MAP3K8) 是 MAP3K 家族中的丝氨酸/苏氨酸激酶，位于 ERK 通路中 MEK 的上游[1]。
Cancer Osaka thyroid (COT) 激酶 (Tpl2) 是巨噬细胞中促炎细胞因子的重要调节因子[2]。
Tpl2 Kinase Inhibitor 1 (Compound 2p) hydrochloride 也能抑制 MK2 和 p38，在 A431 细胞中的 IC50 分别为 110 μM 和 180 μM[1]。
Tpl2 Kinase Inhibitor 1 hydrochloride 抑制脂多糖诱导的人原代单核细胞和人全血中的 TNF-a 的产生，IC50 分别为 0.7 μM 和 8.5 μM[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tpl2 Kinase Inhibitor 1 hydrochloride 相关抗体:
分子量

441.29

Formula

C21H15Cl2FN6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tpl2 Kinase Inhibitor 1 hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tpl2 Kinase Inhibitor 12934185-09-6MAP3Kp38 MAPKMAPKAPK2 (MK2)MAP kinase kinase kinase, MEKK, MAPKKKMitogen-activated protein kinase activated protein kinase 2MAP kinase activated protein kinase 2MAPK activated protein kinase 2MAPKAP kinase 2COTkinaseinflammatorycancerInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Tpl2 Kinase Inhibitor 1 hydrochloride
目录号：
HY-12358A
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z