1. Signaling Pathways
  2. Anti-infection
  3. Arenavirus

Arenavirus

An arenavirus is a virus which is a member of the family Arenaviridae. These viruses infect rodents and occasionally humans.

Arenaviruses are a diverse family of small, enveloped, single-stranded RNA viruses which are generally propagated through asymptomatic, chronic infection of specific rodent hosts. Several arenaviruses are significant human pathogens, including five distinct hemorrhagic fever viruses designated category A by the CDC and NIAID, which is indicative of the level of highest threat to civilian populations. Several arenaviruses, including Lassa virus (LASV), are causative agents of hemorrhagic fever, for which effective therapeutic options are lacking.

The convergence of sensitivity to diverse small-molecule inhibitors thus identifies a robust new target for arenavirus antiviral discovery within the viral entry phase.

Arenavirus 相关产品 (7):

Cat. No. Product Name Effect Purity
  • HY-101441
    ST-193 Inhibitor 99.78%
    ST-193是有效广谱的arenavirus抑制剂;抑制Guanarito, Junin, Lassa和Machupo病毒的IC50值分别为0.44, 0.62, 1.4 和3.1 nM。
  • HY-114698
    Retro-2 cycl Inhibitor 98.11%
    Retro-2 cycl (RN 1-001) 是一种逆行运输抑制剂。Retro-2 cycl (RN 1-001) 抑制 JCPyV 和 HPV16 伪病毒,IC50 分别为 54 μM 和 160 μM。
  • HY-14805
    Tecovirimat 99.88%
    Tecovirimat(ST-246)是口服活性的抗痘病毒化合物,强效选择性对抗多种正痘病毒,EC50值约为10nM。
  • HY-N1970
    5,7-Dihydroxychromone Activator
    5,7-Dihydroxychromone 是一种 Cudrania tricuspidata 的提取物,可以激活 Nrf2/ARE 信号并对 6-OHDA 诱导的氧化应激和细胞凋亡发挥神经保护作用。5,7-Dihydroxychromone 抑制 6-OHDA 诱导的 SH-SY5Y 细胞中活化的 caspase-3caspase-9 以及切割的 PARP 的表达。
  • HY-101441A
    ST-193 hydrochloride Inhibitor 98.22%
    ST-193 hydrochloride是有效广谱的arenavirus抑制剂;抑制Guanarito, Junin, Lassa和Machupo病毒的IC50值分别为0.44, 0.62, 1.4 和3.1 nM。
  • HY-112762
    LHF-535 Inhibitor 98.82%
    LHF-535 是一种抗病毒剂,对 Lassa,Machupo,Junin,VSVg 病毒的 EC50 分别为 <1 μM,<1 μM,<1 μM 和 1-10 μM,详细信息请参考专利文献 WO2012006552A1 中的化合物 1。
  • HY-P0323
    GP(33-41) Inhibitor
    GP(33-41) 是一种由 9 个氨基酸残基组成的多肽,它是淋巴细胞性脉络丛脑膜炎病毒 GP1 抗原决定基中的最佳序列,能够上调 RMA-S (Db Kb) 细胞表面 H-2Db 分子,SC50 值为 344 nM。
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