1. Signaling Pathways
  2. Anti-infection
  3. RSV

RSV (呼吸道合胞病毒)

RSV (Respiratory syncytial virus) is a leading cause of acute respiratory infections. RSV can exploit host immunity and cause a strong inflammatory response that leads to lung damage and virus dissemination. There is a single RSV serotype with two major antigenic subgroups, A and B.

RSV is a non-segmented negative-sense single-stranded enveloped RNA virus that belongs to the family of Paramyxoviridae, genus Pneumovirus, subfamily Pneumovirinae. Its 10 genes encode 11 proteins since two overlapping open reading frames in the M2 mRNA yield two distinct matrix proteins, M2-1 and M2-2. The viral envelope contains three proteins, the G glycoprotein, the fusion (F) glycoprotein, and the small hydrophobic (SH) protein. The RSV virus comprises five other structural proteins, the large (L) protein, nucleocapsid (N), phosphoprotein (P), matrix (M), and M2-1, and two non-structural proteins (NS1 and NS2).

RSV 相关产品 (11):

目录号 产品名 作用方式 纯度
  • HY-B0434
    Ribavirin Inhibitor ≥98.0%
    Ribavirin (ICN-1229) 是广谱的抗病毒药,可抑制HCVHIVlRSV等病毒。
  • HY-15455
    Roflumilast Inhibitor 99.43%
    Roflumilast 是一种选择性的 PDE4 抑制剂,作用于 PDE4A1PDEA4PDEB1PDEB2IC50 分别为 0.7,0.9,0.7 和 0.2 nM。
  • HY-N0662
    Amentoflavone Inhibitor 98.08%
    穗花杉双黄酮 (Amentoflavone) 是一种天然的双黄酮类化合物,具有很多生物活性,包括抗炎、抗氧化、神经保护等作用。
  • HY-12993
    RSV604 Inhibitor 99.96%
    RSV604 (A-60444) 是呼吸道合胞病毒 (RSV) 复制的抑制剂。RSV604 靶向核衣壳蛋白,Kd 值为 1.6 μM。RSV604 表现出针对 RSV A 和 B 亚型的众多临床分离株的亚微摩尔活性 (平均 EC50=0.8 μM)。
  • HY-12283
    Rostafuroxin Inhibitor 98.07%
    Rostafuroxin (PST 2238) 是一种洋地黄毒苷衍生物,一种口服有效的 Na+,K+-ATPase (ATP1A1) 抑制剂。Rostafuroxin 与 ATP1A1 胞外域特异性结合,并阻断呼吸道合胞病毒 (RSV) 触发的 EGFR Tyr845 磷酸化。Rostafuroxin 具有抗高血压和抗 RSV 活性。
  • HY-12993A
    RSV604 racemate Inhibitor 98.37%
    RSV604 (A-60444) racemate 是一种外消旋混合物,与S-异构体相比,RSV604 racemate 对呼吸道合胞病毒(RSV)菌株的作用效果弱很多。
  • HY-112673
    RSV-IN-1 Inhibitor 99.83%
    RSV-IN-1 是人呼吸道合胞病毒 (hRSV) 的抑制剂,其 IC50 值为 0.11 μM。
  • HY-124512
    Quercetin pentaacetate Inhibitor
    Quercetin pentaacetate 可与 F 蛋白相互作用,结合能低、稳定性好、可阻断病毒粘附。Quercetin pentaacetate 可与RSV 相互作用,抑制病毒在细胞表面粘附。
  • HY-N3811
    ent-11β-Hydroxyatis-16-ene-3,14-dione Inhibitor
    ent-11β-Hydroxyatis-16-ene-3,14-dione (compound 11) 是一种来自大戟 (Euphorbia jolkinii) 新鲜根的二萜类化合物。ent-11β-Hydroxyatis-16-ene-3,14-dione 具有抗 RSV 活性。
  • HY-126033
    Sophoranol Inhibitor
    Sophoranol 是一种能从 S. flavescens 中分离得到的生物碱,具有抗病毒活性。Sophoranol 具有抗乙型肝炎病毒 (HBV) 活性。Sophoranol 对呼吸道合胞病毒 (RSV) 具有较强的抗病毒活性,其 IC50 值为 10.4 μg/mL。
  • HY-100285
    RD3-0028 Inhibitor
    RD3-0028是有效和选择性的 RSV 复制抑制剂,EC50 值为4.5 μM。
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