2. PROTAC Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor Apoptosis
  3. PROTACs ROR Apoptosis
  4. PROTAC ROR1 degrader-1

PROTAC ROR1 degrader-1 (Compound 11d) 是伪激酶 ROR1 的 PROTAC 降解剂，可在 NSCLC 细胞中降解 ROR1，DC50 为 40-80 nM。PROTAC ROR1 degrader-1 可导致 PARP 裂解并诱导 NCI-H23 细胞凋亡 (apoptosis)。(Pink: ligand for target protein ROR1 ligand-1 (HY-170996); Black: linker (HY-W014787); Blue: ligand for VHL E3 ligase (S,R,S)-AHPC (HY-125845))

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PROTAC ROR1 degrader-1 Chemical Structure

PROTAC ROR1 degrader-1 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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PROTAC ROR1 degrader-1 相关抗体

Top Publications Citing Use of Products

查看 PROTACs 亚型特异性产品:

查看所有亚型
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

查看 ROR 亚型特异性产品:

查看所有亚型
RORγ RORα RORβ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PROTAC ROR1 degrader-1 (Compound 11d) is a PROTAC degrader for pseudokinase ROR1 that degrades ROR1 in NSCLC cells with a DC50s of 40-80 nM. PROTAC ROR1 degrader-1 causes the cleavage of PARP and induces apoptosis in NCI-H23[1]. (Pink: ligand for target protein ROR1 ligand-1 (HY-170996); Black: linker (HY-W014787); Blue: ligand for VHL E3 ligase (S,R,S)-AHPC (HY-125845))

分子量

1081.22

Formula

C55H74BrN11O5S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PROTAC ROR1 degrader-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC ROR1 degrader-1PROTACsRORApoptosisRAR-related orphan receptorNSCLCNCI-H23NCI-H1299NCI-H1975NCI-H460Inhibitorinhibitorinhibit

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产品名称：
PROTAC ROR1 degrader-1
目录号：
HY-170995
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