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Sulodexide solution  (Synonyms: 舒洛地特注射液)

目录号: HY-100897A
产品使用指南 技术支持

Sulodexide solution 是一种可用于注射的糖胺聚糖混合物,由低分子量肝素 (80%) 和硫酸皮肤素 (20%) 组成。Sulodexide 通过与抗凝血酶 III (AT III) 和肝素辅因子 II (HC II) 相互作用并抑制凝血酶形成而表现出抗血栓活性。Sulodexide 通过释放组织纤溶酶原激活剂 (tPA) 发挥促纤溶活性。Sulodexide 具有内皮保护和抗炎作用,可改善慢性静脉疾病。

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Sulodexide solution

Sulodexide solution Chemical Structure

CAS No. : 57821-29-1

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2 mL ¥2205
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Other Forms of Sulodexide solution:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sulodexide solution is a mixture of glycosaminoglycans that can be administered by injection. It is composed of low molecular weight heparin (80%) and dermatan sulfate (20%). Sulodexide exhibits antithrombotic activity through interaction with antithrombin III (AT III) and heparin cofactor II (HC II), and inhibition of thrombin formation. Sulodexide exhibits profibrinolytic activity through release of tissue plasminogen activator (tPA). Sulodexide exhibits endothelial protective and anti-inflammatory effect, ameliorates chronic venous disease.

体外研究
(In Vitro)

Sulodexide (0–200 μg/mL, 24 小时) 促进小鼠系膜细胞中纤连蛋白和 III 型胶原的合成[2]
Sulodexide (50 µg/mL, 48 小时) 显著抑制肝窦内皮细胞中毛细血管化标志物的表达[4]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Sulodexide (5 mg/kg 和 15 mg/kg, 每日一次, 腹腔注射, 持续 5 天) 在氧诱导的视网膜病 ICR 小鼠模型中显著抑制了视网膜新生血管的形成并抑制了促血管生成蛋白的表达[3]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CAS 号
性状

液体

中文名称

舒洛地特注射液

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Store at 4°C, do not freeze

纯度 & 产品资料
参考文献

Sulodexide solution 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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