2. Metabolic Enzyme/Protease Immunology/Inflammation Anti-infection
  3. Thrombin Interleukin Related RSV
  4. Bivalirudin

Bivalirudin  (Synonyms: 比伐卢定)

目录号: HY-P1929 纯度: 99.97%
COA 产品使用指南 技术支持

Bivalirudin 是水蛭素类似物和抗凝血剂，是一种直接凝血酶抑制剂。Bivalirudin 通过可逆性结合凝血酶，抑制凝血酶介导的纤维蛋白原裂解、凝血因子活化及血小板激活。此外，Bivalirudin 还具有一定的抗病毒、抗炎和血管内皮屏障功能保护的作用。Bivalirudin 可用于血栓性疾病等研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Custom Peptide Synthesis

Bivalirudin

Bivalirudin Chemical Structure

CAS No. : 128270-60-0

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
5 mg ￥550
In-stock
10 mg ￥900
In-stock
25 mg ￥1350
In-stock
50 mg ￥1750
In-stock
100 mg ￥2280
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Bivalirudin:

Bivalirudin 相关抗体

Top Publications Citing Use of Products

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bivalirudin, a hirudin analog and anticoagulant, is a direct thrombin inhibitor. Bivalirudin inhibits thrombin-mediated fibrinogen cleavage, coagulation factor activation, and platelet activation by reversibly binding to thrombin. In addition, Bivalirudin also has certain effects of anti-virus, anti-inflammation, and vascular endothelial barrier function protection. Bivalirudin can be used for the research of thrombotic diseases and others[1][2][3][4].

IC50 & Target[2]

IL-6

 

IL-5

 

体外研究
(In Vitro)

Bivalirudin (30 μg/mL; 10 min) 在 HUVECs 中抑制了 Thrombin (HY-114164) 诱导的 S1PR2 表达增加及细胞通透性升高，并逆转了细胞骨架蛋白和 β-连环蛋白的异常分布[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Bivalirudin 相关抗体:

Western Blot Analysis[1]

Cell Line: HUVECs treated Thrombin (HY-114164)
Concentration: 30 μg/mL
Incubation Time: 10 min
Result: Inhibited the level of S1PR2.
体内研究
(In Vivo)

Bivalirudin (2 mg/kg; 静脉注射; 隔日一次; 2 周) 在新生 C57BL/6 小鼠中具有抗呼吸道合胞病毒的活性[2]。
Bivalirudin (2 mg/kg; 静脉注射; 单剂量) 在小鼠中可抑制血栓形成[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice aged 5-7 days old treated respiratory syncytial virus (RSV)[2]
Dosage: 2 mg/kg
Administration: Intravenous injection; every other day; 2 weeks
Result: Significantly reduced cellular infiltration, inflammatory cytokines (e.g., IL-5, IL-6, CXCL1), and abnormal clotting parameters (e.g., D-dimer, soluble thrombomodulin) in RSV-infected lungs.
Normalized viral copy numbers and reversed histopathological changes such as nuclear pyknosis in pneumocytes.
Animal Model: P2Y12-- and WT mice with thrombosis induced by perfusion through type III collagen- or tissue factor-coated capillary chambers, and P2Y12+- mice with mesenteric artery injury induced by 12.5% FeCl3 solution[3]
Dosage: 2 mg/kg
Administration: Intravenous injection; single dose
Result: Significantly inhibited thrombus volume in P2Y12-- mice in the type III collagen-induced thrombosis model but had no significant effect in wild-type mice.
Inhibited thrombosis in both WT and P2Y12-- mice in the tissue factor-induced thrombosis model.
Delayed the time of thrombus appearance and vessel occlusion, but could not completely prevent vessel occlusion in wild-type mice in the FeCl3-induced mesenteric artery injury model in P2Y12+- mice.
Clinical Trial
分子量

2180.29

Formula

C98H138N24O33
CAS 号
性状

固体

颜色

White to off-white

Sequence

{d-Phe}-Pro-Arg-Pro-Gly-Gly-Gly-Gly-Asn-Gly-Asp-Phe-Glu-Glu-ILE-Pro-Glu-Glu-Tyr-Leu
Sequence Shortening

{d-Phe}-PRPGGGGNGDFEEIPEEYL
中文名称

比伐卢定
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 10 mg/mL (4.59 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.4587 mL 2.2933 mL 4.5865 mL
5 mM --- --- ---
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 99.97%

COA (285 KB) LCMS (87 KB) 元素分析报告 (209 KB)

产品使用指南 (1538 KB)
参考文献

Bivalirudin 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.4587 mL 2.2933 mL 4.5865 mL 11.4664 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bivalirudin128270-60-0比伐卢定ThrombinInterleukin RelatedRSVILRespiratory syncytial viruspeptideanticoagulantanticoagulationinvasivecardiologypercutaneouscoronaryplateletsInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Bivalirudin
目录号：
HY-P1929
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z