1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. Dihydroorotate Dehydrogenase

Dihydroorotate Dehydrogenase

Dihydroorotate dehydrogenase (DHODH) is an enzyme that in humans is encoded by the DHODH gene on chromosome 16. DHODH is an enzyme that localizes to the inner mitochondrial membrane. It is the fourth and rate limiting step of the de novo pyrimidine synthesis pathway, converting dihydroorotate (DHO) to orotate. Inhibition of dihydroorotate dehydrogenase (DHODH), a key enzyme in the de novo pyrimidine synthesis pathway, induces differentiation of diverse acute myeloid leukemia (AML) subtypes. Human dihydroorotate dehydrogenase (HsDHODH) is a key enzyme of pyrimidine de novo biosynthesis pathway. Inhibitors of DHODH are used to treat autoimmune diseases such as rheumatoid arthritis.

Dihydroorotate Dehydrogenase 相关产品 (10):

Cat. No. Product Name Effect Purity
  • HY-112645
    BAY-2402234 Inhibitor 99.92%
    BAY-2402234 是一个选择性的、二氢乳清酸脱氢酶 (DHODH) 的抑制剂,可用于骨髓恶性肿瘤 (myeloid malignancies)的相关研究。
  • HY-108325
    Brequinar Inhibitor 99.57%
    Brequinar (DUP785) 是一种有效的 dihydroorotate dehydrogenase (DHODH) 抑制剂,对人 IC50 值为 5.2 nM,也是一种广谱的抗病毒剂。
  • HY-15510
    Tenovin-6 Inhibitor 98.61%
    Tenovin-6 是 Tenovin-1 (HY-13423) 的类似物,是一种 p53 转录活性的激活剂。Tenovin-6 Hydrochloride 抑制纯化人 SIRT1、SIRT2 和 SIRT3 蛋白脱乙酰酶活性,IC50 分别为 21 μM、10 μM 和 67 μM。Tenovin-6 也能抑制二氢乳清酸脱氢酶 (DHODH)
  • HY-14908
    Vidofludimus Inhibitor 99.14%
    Vidofludimus(4SC-101; SC12267)是免疫抑制剂,能抑制DHODH,在不影响淋巴细胞增殖的条件下抑制IL-17的分泌。
  • HY-13423
    Tenovin-1 Inhibitor 99.88%
    Tenovin-1 是 sirtuin 1sirtuin 2 的抑制剂,同时可激活 p53,具有潜在的癌症研究的潜力。
  • HY-129239
    ASLAN003 Inhibitor 99.95%
    ASLAN003 是一种具有口服活性,有效的二氢乳清酸脱氢酶 (DHODH) 抑制剂,对人 DHODH 酶的 IC50 为 35 nM。ASLAN003 通过激活 AP-1 转录因子来抑制蛋白质合成。ASLAN003 可以诱导凋亡 (apoptosis),并在急性髓样白血病 (AML) 异种移植小鼠中大大延长其生存期。
  • HY-15510B
    Tenovin-6 Hydrochloride Inhibitor >98.0%
    Tenovin-6 Hydrochloride 是 Tenovin-1 (HY-13423) 的类似物,是一种 p53 转录活性的激活剂。Tenovin-6 Hydrochloride 抑制纯化人 SIRT1、SIRT2 和 SIRT3 蛋白脱乙酰酶活性,IC50 分别为 21 μM、10 μM 和 67 μM。Tenovin-6 Hydrochloride 也能抑制二氢乳清酸脱氢酶 (DHODH)
  • HY-128787
    DHODH-IN-5 Inhibitor 99.75%
    DHODH-IN-5 是一种有效的人二氢硼酸脱氢酶 (DHODH) 抑制剂,人重组 DHODH 的pIC50 为 7.8。DHODH-IN-5 抑制麻疹病毒复制,pMIC50 为 8.8。
  • HY-101813
    Laflunimus Inhibitor 99.26%
    Laflunimus (HR325) 是一种免疫抑制剂和 Leflunomide 活性代谢物 A771726 的类似物。Laflunimus 是一种口服的二氢硼酸脱氢酶 (DHODH) 抑制剂。Laflunimus 抑制免疫球蛋白 (Ig) 分泌,抑制 Ig M 和 IgG 分泌的 IC50 值分别为 2.5 和 2 μM。Laflunimus 也是前列腺素内过氧化物合酶 (PGHS) -1-2 抑制剂。
  • HY-135570
    DHODH-IN-2 Inhibitor 99.86%
    DHODH-IN-2 是人二氢乳清酸脱氢酶 (HsDHODH) 抑制剂,可抑制麻疹病毒复制,pMIC50 值为 8.6。
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