2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. Thiazinamium chloride

Thiazinamium (chloride) 具有有效的抗胆碱和抗过敏活性，并抑制 TxB2 合成其 IC50 值为 0.2 µM。Thiazinamium (chloride) 的结构与 H-1 拮抗剂 Promethazine (HY-B1296) 相似。Thiazinamium (chloride) 可刺激成年大鼠 II 型肺泡细胞分泌磷脂酰胆碱。

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Thiazinamium chloride

Thiazinamium chloride Chemical Structure

CAS No. : 4320-13-2

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Thiazinamium chloride 相关抗体

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  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

Thiazinamium (chloride) possesses potent anticholinergic and antiallergic activity and inhibits TxB2 synthesis with IC50 value of 0.2 µM. Thiazinamium (chloride) is structurally similar to H-1 antagonists Promethazine (HY-B1296). Thiazinamium (chloride) stimulates the phosphatidylcholine secretion in adult rat type II pneumocytes[1][2].

IC50 & Target

IC50: 0.2 µM (TxB2 synthesis)[1]
体外研究
(In Vitro)

TxB2 synthesis by resting macrophages is inhibited by thiazinamium chloride and promethazine in a dose-dependent manner. Thiazinamium chloride inhibits TxBz synthesis but had no effect on the ingestion of zymosan particles. In contrast, chlorpromazine inhibits phagocytosis but not TxBz synthesis except at lo-3 M. Under the condition where indomethacin, a nown cyclooxygenase inhibitor, is inhibitory, promethazine but not thiazinamium chloride inhibits TxB2 synthesis from exogenous arachidonic acid. Treatment of macrophages with promethazine and chlorpromazine but not thiazinamium chloride results in a reduction in the oxidative burst during phagocytosis. Furthermore, the ability of thiazinamium chloride to selectively inhibit arachidonic acid metabolism may contribute to its bronchodilator/antiallergic activity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Thiazinamium chloride 相关抗体:
分子量

334.91

Formula

C18H23ClN2S
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献
Cell Assay
[1]

Rats are anesthetized with an intraperitoneal injections of sodium pentobarbital (43mg/kg body wt) and exsanguinated by cardiac puncture; their lungs are isolated and lavaged with a total of 50mL of lavage solution. Lungs that exhibit infection or gross pathological changes are not used. The lavage fluid containing macrophages is centrifuged at 300g for 10 min, and the cell pellet is resuspended in serum free M199. Macrophage monolayers are established by incubating 1.5x106 cells in petri dishes (35x10mm) for 2 hr in an atmosphere of 95% room air and 5% carbon dioxide. After washing with I-IBSS to remove non-adherent cells, the cultures are incubated in serum-free Ml99 with or without zymosan (100μg/mL) in the absence or presence of drugs(including Thiazinamium chloride)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

Thiazinamium chloride 相关分类

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Keywords:

Thiazinamium4320-13-2Cholinesterase (ChE)Inhibitorinhibitorinhibit

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