Trifluralin (Synonyms: 氟乐灵)

目录号: HY-B2050 纯度: 98.0%: Data Sheet SDS COA 产品使用指南
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Trifluralin 是一种选择性、苗前土壤施用的除草剂，可防除多种重要的一年生禾本科和阔叶杂草。Trifluralin 通过中断有丝分裂来抑制根系发育，从而阻止杂草生长。Trifluralin 与微管蛋白 (tubulin) 结合，导致纺锤体和细胞板形成障碍。Trifluralin 抑制根部胚根的发育。Trifluralin 抑制细胞有丝分裂。Trifluralin 被认为具有神经毒性和血液毒性。

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Trifluralin Chemical Structure

CAS No. : 1582-09-8

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规格	价格	是否有货
Free Sample (0.1 - 0.2 mg)		Apply now
10 mM * 1 mL in DMSO	￥220	In-stock
500 mg	￥200	In-stock
1 g	￥321	In-stock
5 g	￥641	In-stock
10 g	￥1002	In-stock
50 g		询价

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Other Forms of Trifluralin:

Trifluralin-d₁₄ 询价
Trifluralin (Standard) 询价

Trifluralin 相关产品

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•同靶点产品:

•同靶点蛋白产品:

生物活性
纯度 & 产品资料
参考文献

生物活性

Trifluralin is a selective, preemergence, soil-applied herbicide providing control of many important annual grass and broadleaf weed species. Trifluralin prevents weed growth by inhibiting root development through the interruption of mitosis. Trifluralin binds to tubulin and results in the failure of spindle apparatus and cell plate formation. Trifluralin inhibits radicle development on roots. Trifluralin inhibits cell mitosis. Trifluralin is considered to be neurotoxic and haematotoxic^[1]^[2]^[3]^[4].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
HCT-8	IC₅₀	750 nM Compound: 1	Antimicrobial activity against Cryptosporidium parvum infected in HCT8 cells assessed as parasite count after 72 to 120 hrs Antimicrobial activity against Cryptosporidium parvum infected in HCT8 cells assessed as parasite count after 72 to 120 hrs	[PMID: 21889338]
HFF	IC₅₀	0.52 μM Compound: 13	Antimicrobial activity against Toxoplasma gondii RH infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	1.8 μM Compound: 13	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235V mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235V mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	1.9 μM Compound: 13	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235L mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235L mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	13.8 μM Compound: 13	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin V4L mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin V4L mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	2.8 μM Compound: 13	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin S6I mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin S6I mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	23.3 μM Compound: 13	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin R243S mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin R243S mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	23.4 μM Compound: 13	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin T239I mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin T239I mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	27 μM Compound: 13	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin L136F mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin L136F mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	4.1 μM Compound: 13	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin R243C mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin R243C mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	4.2 μM Compound: 13	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin F24H mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin F24H mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	5.1 μM Compound: 13	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235T mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235T mutation infected in HFF cells by plaque assay	[PMID: 20145086]
HFF	IC₅₀	5.3 μM Compound: 13	Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin H28Q mutation infected in HFF cells by plaque assay Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin H28Q mutation infected in HFF cells by plaque assay	[PMID: 20145086]
THP-1	CC₅₀	> 50 μM Compound: TFL	Cytotoxicity against human THP1 cells after 48 hrs by propidium iodide and SYBR14 satining-base flow cytometry Cytotoxicity against human THP1 cells after 48 hrs by propidium iodide and SYBR14 satining-base flow cytometry	[PMID: 19926293]
THP-1	IC₅₀	> 50 μM Compound: TFL	Antileishmanial activity against Leishmania infantum A1 amastigotes infected in human THP1 cells assessed as reduction in intracellular parasite load after 48 hrs by Giemsa staining Antileishmanial activity against Leishmania infantum A1 amastigotes infected in human THP1 cells assessed as reduction in intracellular parasite load after 48 hrs by Giemsa staining	[PMID: 19926293]

体外研究
(In Vitro)

Trifluralin (Compound TFL) (22.3-1000 μg/mL) 对中国仓鼠 V79 细胞和 CHO-K1 细胞有细胞毒性，但无致突变性^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Trifluralin (Compound TFL) (0-5000 mg/kg，饲料中添加，13周) 会导致 Wistar 大鼠绝对食物消耗量减少，同时体重增长也减少^[3]。
Trifluralin (0-500 mg/kg，饲料中添加，妊娠第6-15天) 会对母鼠产生显著毒性，并导致 Wistar 大鼠着床后不久或胚胎早期阶段大量妊娠鼠死亡^[3]。
Trifluralin (0-0.02 mg/L，给药14天) 会增加鲤鱼肝脏和血清中的 AST，以及肾脏中的 ALP 活性^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

335.28

Formula

C₁₃H₁₆F₃N₃O₄

CAS 号

1582-09-8

性状

固体

颜色

Pink to red

中文名称

氟乐灵；氟乐宁

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

溶解性数据

细胞实验：

DMSO 中的溶解度 : ≥ 100 mg/mL (298.26 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	2.9826 mL	14.9129 mL	29.8258 mL
5 mM	0.5965 mL	2.9826 mL	5.9652 mL
10 mM	0.2983 mL	1.4913 mL	2.9826 mL

查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

摩尔计算器
稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)

体积 _(start)

浓度 _(final)

体积 _(final)

动物溶解方案计算器

请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

每只动物的给药体积

μL

动物数量

只

由于实验过程有损耗，建议您多配一只动物的量

计算结果

工作液所需浓度 : mg/mL

纯度 & 产品资料

纯度: 98.0%

选择批次：

Data Sheet (621 KB) SDS (788 KB)

COA (288 KB) HNMR (264 KB)

产品使用指南 (1538 KB)

参考文献

[1]. Grover, R., et al., (1997). Environmental fate of trifluralin. Reviews of environmental contamination and toxicology, 153, 1–64. [Content Brief]

[2]. C. Fernandes, et al., (2013). Characterization, Modes of Action and Effects of Trifluralin: A Review. InTech.

[3]. Ebert, E., et al., (1992). Toxicology and hazard potential of trifluralin. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 30(12), 1031–1044. [Content Brief]

[4]. Poleksić, V., & Karan, V. (1999). Effects of trifluralin on carp: biochemical and histological evaluation. Ecotoxicology and environmental safety, 43(2), 213–221. [Content Brief]

Trifluralin 相关分类

Others

完整储备液配制表

可选溶剂	浓度溶剂体积质量	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.9826 mL	14.9129 mL	29.8258 mL	74.5645 mL
	5 mM	0.5965 mL	2.9826 mL	5.9652 mL	14.9129 mL
	10 mM	0.2983 mL	1.4913 mL	2.9826 mL	7.4565 mL
	15 mM	0.1988 mL	0.9942 mL	1.9884 mL	4.9710 mL
	20 mM	0.1491 mL	0.7456 mL	1.4913 mL	3.7282 mL
	25 mM	0.1193 mL	0.5965 mL	1.1930 mL	2.9826 mL
	30 mM	0.0994 mL	0.4971 mL	0.9942 mL	2.4855 mL
	40 mM	0.0746 mL	0.3728 mL	0.7456 mL	1.8641 mL
	50 mM	0.0597 mL	0.2983 mL	0.5965 mL	1.4913 mL
	60 mM	0.0497 mL	0.2485 mL	0.4971 mL	1.2427 mL
	80 mM	0.0373 mL	0.1864 mL	0.3728 mL	0.9321 mL
	100 mM	0.0298 mL	0.1491 mL	0.2983 mL	0.7456 mL

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Trifluralin1582-09-8氟乐灵氟乐宁HerbicideMicrotubule/TubulinInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Trifluralin (Synonyms: 氟乐灵)

Other Forms of Trifluralin: