1. Neuronal Signaling
  2. Amyloid-β
  3. AC 253

AC 253 是 amylin 的拮抗剂,抑制 125I-adrenomedullin 结合,其IC50 值为 25 nM。

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Custom Peptide Synthesis

AC 253 Chemical Structure

AC 253 Chemical Structure

CAS No. : 151804-79-4

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AC 253, an amylin antagonist, inhibits 125I-adrenomedullin binding, with an IC50 of 25 nM[1].

体外研究
(In Vitro)

AC 253 (5-20 μM) antagonizes adrenomedullin-stimulated cAMP production at micromolar concentrations[1].
AC 253 (5-10 μM) blocks increases in intracellular Ca2+, activation of protein kinase A, MAPK, Akt, cFos, and cell death, which occur upon AMY3 activation with hAmylin, Aβ1-42, or their co-application[2].
AC 253 (10 nM) blocks Aβ1-42-induced electrophysiological effects[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

2847.11

Formula

C122H196N40O39

CAS 号
Sequence

Ac-Leu-Gly-Arg-Leu-Ser-Gln-Glu-Leu-His-Arg-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Asn-Thr-Tyr-NH2

Sequence Shortening

Ac-LGRLSQELHRLQTYPRTNTGSNTY-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

AC 253 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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