1. Metabolic Enzyme/Protease
  2. Tyrosinase
  3. Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2

Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 

目录号: HY-P3662 纯度: 99.95%
COA 产品使用指南

Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 是一种促黑素,一种刺激黑素细胞的激素。Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 能够刺激酪氨酸酶活性并在大鼠模型中表现出体温调节作用。

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Custom Peptide Synthesis

Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 Chemical Structure

Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 Chemical Structure

CAS No. : 82188-67-8

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Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 is a melanotropin, a melanocyte-stimulating hormone. Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 stimulates tyrosinase and exhibits thermoregulatory effect in rats model[1][2].

体外研究
(In Vitro)

Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 (0.1 pM-1 μM; 48 h) stimulates tyrosinase activity in a dose-dependent manner in Cloudman S91 mouse melanoma cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 (0-50 pM; i.c.v.; single dose) exerts thermoregulatory effect in rats model[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat model[2]
Dosage: 0, 0.5, 1, 5, 10, or 50 pM peptide in 0.5 μL sterile saline
Administration: Intracerebroventricular injection in the anterior hypothalamic-preoptic area (AHPOA) of rats; single dose; recorded 0, 10, 20, 30, 40, 50, and 60 min after injection
Result: Showed greater difference than mean temperatures of animals receiving sterile saline group.
分子量

985.10

Formula

C47H64N14O10

CAS 号
性状

固体

颜色

White to off-white

Sequence Shortening

Ac-{Nle}-EH-{d-Phe}-RWG-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

纯度 & 产品资料
参考文献

Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2 相关分类

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  • 稀释计算器

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质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Ac-[Nle4,D-Phe7]-α-MSH (4-10)-NH2
目录号:
HY-P3662
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