2. Protein Tyrosine Kinase/RTK
  3. PDGFR
  4. AC710 Mesylate

AC710 Mesylate 是有效的 PDGFR 抑制剂，对FLT3，CSF1R，KIT，PDGFRα 和 PDGFRβ的Kd 值分别为0.6，1.57，1，1.3，1.0。

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AC710 Mesylate Chemical Structure

AC710 Mesylate Chemical Structure

CAS No. : 1351522-05-8

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AC710 Mesylate 的其他形式现货产品:

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AC710 Mesylate 相关抗体

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PDGFR PDGFRβ PDGFRα

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

AC710 Mesylate is a potent PDGFR inhibitor with Kds of 0.6, 1.57, 1, 1.3, 1.0 nM for FLT3, CSF1R, KIT, PDGFRα and PDGFRβ, respectively.

IC50 & Target[1]

PDGFRα

1.3 nM (Kd)

PDGFRβ

1 nM (Kd)

c-Kit

1 nM (Kd)

FLT3

0.6 nM (Kd)

CSF1R

1.57 nM (Kd)

体内研究
(In Vivo)

At 0.3 mg/kg of AC710, tumor growth is temporally inhibited, and growth resumes quickly thereafter. At 3 and 30 mg/kg of AC710, tumors regress completely, and the tumor volume stay suppressed for an extended period after dosing is halted. No body weight loss is observed in animals treated with AC710 at all doses, indicating that it is well tolerated in mice at efficacious doses. AC710 exhibits a significant impact on disease in a dose-dependent fashion in a mouse collagen-induced arthritis (CIA) model, at a dose as low as 3 mg/ kg for 15 days (day 0-14). At 10 and 30 mg/kg, AC710 demonstrates equivalent or slightly better efficacy in reducing the joint swelling and inflammation than dexomethasone administered at a safe dose. AC710 is well tolerated at the tested doses[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

658.81

Formula

C32H46N6O7S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献
Animal Administration
[1]

Mice: The antitumor efficacy of AC710 is assessed in a subcutaneous flank-tumor xenograft model in athymic nude mice using the MV4-11cell line. AC710 is dosed at 0.3, 3, and 30 mg/kg for 2 weeks. Tumor growth and body weight is monitored[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

AC710 Mesylate 相关分类

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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AC7101351522-05-8AC 710AC-710PDGFRPlatelet-derived growth factor receptorInhibitorinhibitorinhibit

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产品名称：
AC710 Mesylate
目录号：
HY-13493A
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