1. Metabolic Enzyme/Protease
  2. Drug Metabolite Endogenous Metabolite
  3. Acetaminophen glucuronide

Acetaminophen glucuronide  (Synonyms: APAP-glu)

目录号: HY-113083 纯度: ≥99.0%
COA 产品使用指南

Acetaminophen glucuronide (APAP-glu) 是 Acetaminophen (HY-66005) 的无活性葡萄糖醛酸代谢物。Acetaminophen 是一种选择性环氧合酶 2 (COX-2) 抑制剂,也是有效的肝 N-乙酰转移酶 2 (NAT2) 抑制剂。

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Acetaminophen glucuronide Chemical Structure

Acetaminophen glucuronide Chemical Structure

CAS No. : 16110-10-4

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Acetaminophen glucuronide (APAP-glu) is an inactive glucuronide metabolite of Acetaminophen (HY-66005)[1][2]. Acetaminophen is a selective cyclooxygenase-2 (COX-2) inhibitor and a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[3][4].

IC50 & Target

Human Endogenous Metabolite

 

体外研究
(In Vitro)

Acetaminophen is metabolized in the liver mainly by glucuronidation and sulfation, thus generating the nontoxic metabolites, Acetaminophen glucuronide (APAP-glu). Acetaminophen glucuronide is a substrate for both canalicular Mrp2 and basolateral Mrp3 in rodents[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

327.29

Formula

C14H17NO8

CAS 号
性状

固体

颜色

White to off-white

中文名称

对乙酰氨基酚葡萄糖醛酸

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥99.0%

参考文献

Acetaminophen glucuronide 相关分类

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Acetaminophen glucuronide
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HY-113083
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