2. Protein Tyrosine Kinase/RTK
  3. PDGFR
  4. AG 370

AG 370 是一种吲哚 tyrphostin，是一种有效的 PDGF 诱导的有丝分裂抑制剂 (IC50 为 20 μM)。AG 370 对 EGF 受体的抑制作用较弱。

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AG 370 Chemical Structure

AG 370 Chemical Structure

CAS No. : 134036-53-6

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规格 价格 是否有货 数量
1 mg ￥1188
3 - 4 周
5 mg   询价  
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AG 370 相关抗体

Top Publications Citing Use of Products

查看 PDGFR 亚型特异性产品:

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PDGFR PDGFRβ PDGFRα

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AG 370, an indole tyrphostin, is a potent PDGF-induced mitogenesis inhibotor (IC50 of 20 μM). AG 370 displays weak inhibition of the EGF receptor[1].

IC50 & Target[1]

PDGFR

20 μM (IC50)

体外研究
(In Vitro)

AG 370 blocks mitogenesis induced by epidermal growth factor (IC50 of 50 μM) and human serum (IC50 of 50 μM)[1][1].
In Digitonin-permeabilized fibroblasts as well as in intact fibroblasts, tyrphostin AG 370 inhibits PDGF receptor autophosphorylation and the tyrosine phosphorylation of intracellular protein substrates (pp120, pp85, and pp75) which coprecipitate with the PDGF receptor[1][1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AG 370 相关抗体:
分子量

259.27

Formula

C15H9N5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AG 370 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AG 370134036-53-6AG370AG-370PDGFRPlatelet-derived growth factor receptormitogenesisautophosphorylationtyrosine phosphorylationInhibitorinhibitorinhibit

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产品名称：
AG 370
目录号：
HY-116111
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