2. Antibody-drug Conjugate/ADC Related Metabolic Enzyme/Protease
  3. Antibody-Drug Conjugates (ADCs) Phosphodiesterase (PDE)
  4. AGS-16C3F

AGS-16C3F 是一种靶向 ENPP3 的抗体-药物偶联物 (ADC)。AGS-16C3F由靶向 ENPP3 的Anti-ENPP3/CD203c Antibody (HY-P990315) 通过连接子与 Monomethyl auristatin F (HY-15579) 连接而成。AGS-16C3F 具有抗肿瘤活性，可用于转移性肾细胞癌 (mRCC) 的研究。

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AGS-16C3F

AGS-16C3F Chemical Structure

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规格 价格 是否有货
1 mg ￥4320
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AGS-16C3F 相关抗体

Top Publications Citing Use of Products

查看 Phosphodiesterase (PDE) 亚型特异性产品:

查看所有亚型
PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AGS-16C3F is an antibody-drug conjugate (ADC) targeting ENPP3. AGS-16C3F is composed of ENPP3-targeting Anti-ENPP3/CD203c Antibody (HY-P990315) linked to Monomethyl auristatin F (HY-15579) via a linker. AGS-16C3F has anti-tumor activity and can be used in the study of metastatic renal cell carcinoma (mRCC)[1][2].

IC50 & Target

PDE3

 

体外研究
(In Vitro)

AGS-16C3F (0.001-1350 nM, 96 h) 在 ROSA KIT D816V，ROSA KIT D816V-Gluc， HMC-1.1 和 HMC-1.2细胞中，IC50 分别为 1.1 nM，2.73 nM，109.9 nM 和 146.5 nM，表现出对 CD203c 高表达的 ROSA 细胞具有强效的抑制增殖活性[2]。
AGS-16C3F (0.5-100 nM, 96-120 h) 在 ROSA KIT D816V，ROSA KIT D816V-Gluc，HMC-1.1 和 HMC-1.2细胞中，诱导凋亡杀伤 CD203c 高表达的肿瘤细胞[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AGS-16C3F 相关抗体:

Apoptosis Analysis[2]

Cell Line: ROSA KIT D816V, ROSA KIT D816V-Gluc, HMC-1.1 and HMC-1.2 cells
Concentration: 0.5-100 nM
Incubation Time: 96-120 h
Result: Significantly increased the proportion of apoptotic cells in ROSA cells (dose-dependent).
Had a low apoptosis rate in HMC-1 cells.
体内研究
(In Vivo)

AGS-16C3F (1,4 mg/kg, i.v. 每 4 天 1 次，共 4 次) 在移植了 ROSA KIT D816V-Gluc 细胞的 NOD-SCID γ 小鼠模型中，显著降低肿瘤负荷，延长生存期，且无明显毒性[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NOD-SCID γ mice injected with ROSA KIT D816V-Gluc (5 million cells)[2]
Dosage: 1,4 mg/kg
Administration: i.v. once every 4 days, 4 times in total
Result: Significantly reduced the number of tumor cells in peripheral blood, bone marrow, and spleen, and decreased serum tryptase levels.
During treatment and after drug withdrawal, the luciferase activity (marker of tumor burden) of mice in the high-dose group continued to be lower than that in the control group, and disease recurrence was delayed.
Significantly prolonged the survival of mice.
Showed a significant increase in apoptotic cells in the mouse bone marrow, indicating that the anti-tumor effect was mainly achieved by inducing apoptosis.
Clinical Trial
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AGS-16C3F 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AGS-16C3FAGS-16M8FAntibody-Drug Conjugates (ADCs)Phosphodiesterase (PDE)Antibody-Drug ConjugatesMrccADCsROSA KIT D816V cellsHMC cellsInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-171544
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