Anti-CD3 Antibody (OKT-3) 

Anti-CD3 Antibody (OKT-3) is a kind of mouse IgG2a κ antibody inhibitor, targeting to human CD3. Anti-CD3 Antibody (OKT-3) decreases T cells. Anti-CD3 Antibody (OKT-3) can be used for the research of immunology, such as graft-versus-host disease^[1][2][3].

Mouse IgG2a kappa

Mouse IgG2a kappa, Isotype Control

Mouse

CD3

Anti-CD3 Antibody (OKT-3) (1 μg/mL, 24-36 h) 可减少 huCD3ε^HET 细胞中 CD4 阳性和 CD8 阳性 T 细胞的数量^[1]。
Anti-CD3 Antibody (OKT-3) (1-1000 ng/mL, 2 h) 可导致人外周血单个核细胞显著增殖^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-CD3 Antibody (OKT-3) (20 μg/mouse，静脉注射，单剂量) 可导致注入人外周血单个核细胞 (PBMC) 的 NOG 小鼠体内多种细胞因子，如 IL-2、 TNF-α 的全身性释放^[2]。
Anti-CD3 Antibody (OKT-3) (10 mg/kg，腹腔注射，单剂量) 可预防人外周血/脐带血诱导的移植物抗宿主病小鼠模型中小鼠的移植物抗宿主病^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

916  [NCBI]

P07766

ELISA, FACS, Functional assay, Research in vivo

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

液体

Colorless to light yellow

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Crespo J, et al. A humanized CD3ε-knock-in mouse model for pre-clinical testing of anti-human CD3 therapy. PLoS One. 2021 Feb 17;16(2):e0245917.  [Content Brief]

  [2]. Shiheido H, et al. Modulation of the human T cell response by a novel non-mitogenic anti-CD3 antibody. PLoS One. 2014 Apr 7;9(4):e94324.  [Content Brief]

  [3]. Wunderlich M, et al. OKT3 prevents xenogeneic GVHD and allows reliable xenograft initiation from unfractionated human hematopoietic tissues. Blood. 2014 Jun 12;123(24):e134-44.  [Content Brief]