2. Anti-infection
  3. Influenza Virus
  4. Anti-IAV agent 1

Anti-IAV agent 1 (Compound (R)-1a) 是一种具有口服活性的抗甲型流感病毒 (IAV) 剂，对 IAV H1N1 和 Oseltamivir 抗性 IAV H1N1 的 IC50 分别为 0.03 μM 和 0.06 μM。

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Anti-IAV agent 1 Chemical Structure

Anti-IAV agent 1 Chemical Structure

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Anti-IAV agent 1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-IAV agent 1 (Compound (R)-1a) is an orally active anti-influenza A virus (IAV) agent with IC50s of 0.03 and 0.06 μM against IAV H1N1 and Oseltamivir-resistant IAV H1N1 strains, respectively[1].

体内研究
(In Vivo)

Anti-IAV agent 1 (Compound (R)-1a) (1.67-15 mg/kg; p.o.; twice daily for 7 days) 在小鼠中显示出抗甲型流感病毒活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Kunming Mice lethal challenge model with H1N1 A/Puerto Rico/8/1934 virus[1]
Dosage: 1.67, 5 and 15 mg/kg
Administration: Oral administration, twice daily for 7 days
Result: Improved the survival rate.
Animal Model: Balb/c mice[1]
Dosage: 25 mg/kg
Administration: Oral administration (Pharmacokinetic Analysis)
Result: PK property in Balb/c mice after a single oral administration of 25 mg/kg, n = 3.
Compd. T1/2 (h) Tmax (h) Cmax (ng/mL) AUC0-inf
(ng⋅h/mL)		 ahERG IR (n = 3)
Anti-IAV agent 1 (Compound (R)-1a) 5.84 ± 0.63 0.33 ± 0 866 ± 205 1913 ± 554 13.2 ± 2.87%

ahERG ion channel inhibition rate at 10 μM, n = 3. Abbreviations: T1/2, elimination half-life; Tmax, the time at which the Cmax is observed; Cmax, the maximum serum concentration; AUC0-inf, area under the concentration-time curve up to infinite time; hERG, human Ether-a-gogo related gene.
分子量

557.58

Formula

C28H28FN9O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-IAV agent 1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-IAV agent 1Influenza VirusIAVH1N1Kunming MiceA/Puerto Rico/8/1934Inhibitorinhibitorinhibit

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产品名称：
Anti-IAV agent 1
目录号：
HY-151967
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