2. Immunology/Inflammation
  3. CD20
  4. Anti-Monkey/Human CD20 Antibody (2H7)

Anti-Monkey/Human CD20 Antibody (2H7) 

目录号: HY-P990138
技术支持

Anti-Monkey/Human CD20 Antibody (2H7) 是一种小鼠源性 IgG2b κ 型抗体抑制剂，靶向猴/人 CD20。Anti-Monkey/Human CD20 Antibody (2H7) 可特异性清除 B 细胞。Anti-Monkey/Human CD20 Antibody (2H7) 可用于炎症和代谢性疾病的研究，如糖尿病和实验性自身免疫性脑脊髓炎。

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Anti-Monkey/Human CD20 Antibody (2H7)

Anti-Monkey/Human CD20 Antibody (2H7) Chemical Structure

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Anti-Monkey/Human CD20 Antibody (2H7) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Monkey/Human CD20 Antibody (2H7) is a mouse-derived IgG2b κ type antibody inhibitor, targeting to monkey/human CD20. Anti-Monkey/Human CD20 Antibody (2H7) specifically depletes B cells. Anti-Monkey/Human CD20 Antibody (2H7) can be used for the researches of inflammation and metabolic disease, such as diabetes and experimental autoimmune encephalomyelitis[1][2].

同型

Mouse IgG2b kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

CD20
体外研究
(In Vitro)

抗体框架具有稳定性、特异性和适应性，同时具有结合抗原和内源免疫受体。 单克隆抗体具有几种衍生物，包括双特异性抗体、抗体-药物缀合物和抗体片段，在免疫学和肿瘤学等领域具有显著效果。 设计抑制性抗体时，需要注意包括抗原特异性可变区的鉴定、表达系统的选择、多特异性形式的使用以及基于片段化、寡聚化或与其他功能部分缀合的抗体衍生物[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Monkey/Human CD20 Antibody (2H7) 相关抗体:
体内研究
(In Vivo)

Anti-Monkey/Human CD20 Antibody (2H7) (0.25-0.5 mg/kg，静脉注射，9 天内每隔 3 天注射 4 次) 可有效清除 B 细胞，并延缓非肥胖糖尿病的人 CD20 转基因 NOD 小鼠中糖尿病的进展[1]。
Anti-Monkey/Human CD20 Antibody (2H7) (200 μg，腹腔注射，每周一次) 可预防或逆转人 CD20 转基因 C57BL/6 小鼠中髓鞘少突胶质细胞糖蛋白诱导的实验性自身免疫性脑脊髓炎 (EAE)[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Spontaneous diabetes mice models (hCD20-transgenic NOD mice)[1]
Dosage: 0.5 mg antibody in the first injection and 0.25 mg for the subsequent 3 injections
Administration: Intravenously injection, 9-day period with 4 injections at 3-day intervals
Result: Significantly delayed the progression of diabetes.
Showed significantly less infiltration of pancreatic islets.
Animal Model: MOG-induced experimental autoimmune encephalomyelitis (EAE) mice models (hCD20 transgenic C57BL/6 mice)[2]
Dosage: 200 μg
Administration: Intraperitoneally injection, weekly
Result: Depleted 60% of B cells within established CNS lesions.
Suppressed development of proinflammatory T cells and clinical EAE.
基因 ID

931  [NCBI]

Accession

P11836-1
分子量

150 kDa

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-Monkey/Human CD20 Antibody (2H7) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Monkey/Human CD20 Antibody (2H7)CD20B cellsDiabetes,Experimental autoimmune encephalomyelitisMyelin oligodendrocyte glycoproteinInhibitorinhibitorinhibit

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