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  4. Anti-Mouse CD3ε Antibody (145-2C11)

Anti-Mouse CD3ε Antibody (145-2C11) 

目录号: HY-P990802 纯度: 95.00%
COA 技术支持

Anti-Mouse CD3ε Antibody (145-2C11) 是一种口服有效的抗小鼠 CD3ε IgG1 单克隆抗体。Anti-Mouse CD3ε Antibody (145-2C11) 可以抑制效应 T 细胞的增殖并改善调节性 T 细胞 (Tregs) 的功能。Anti-Mouse CD3ε Antibody (145-2C11) 通过抑制促炎细胞因子的产生和增加抗炎因子的分泌来缓解炎症反应。Anti-Mouse CD3ε Antibody (145-2C11) 可用于研究代谢和免疫系统疾病，如糖尿病和狼疮。Anti-Mouse CD3ε Antibody (145-2C11) 的同型对照为 Armenian hamster IgG, Isotype Control (HY-P990305)。

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Anti-Mouse CD3ε Antibody (145-2C11)

Anti-Mouse CD3ε Antibody (145-2C11) Chemical Structure

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5 mg ￥3600
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Anti-Mouse CD3ε Antibody (145-2C11) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse CD3ε Antibody (145-2C11) is an orally active anti-mouse CD3ε IgG1 monoclonal antibody. Anti-Mouse CD3ε Antibody (145-2C11) can inhibit the proliferation of effector T cells and improve the function of regulatory T cells (Tregs). Anti-Mouse CD3ε Antibody (145-2C11) relieves inflammatory response by inhibiting the production of pro-inflammatory cytokines and increasing the secretion of anti-inflammatory factors. Anti-Mouse CD3ε Antibody (145-2C11) can be used for researches on metabolic and immune system conditions such as diabetes and lupus. The recommend isotype control of Anti-Mouse CD3ε Antibody (145-2C11): Armenian hamster IgG, Isotype Control (HY-P990305)[1][2].

同型

Armenian hamster IgG
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

CD3ε
体外研究
(In Vitro)

Anti-Mouse CD3ε Antibody (145-2C11) (0.04-1 μg/mL，72 小时) 显著降低了脾细胞的增殖[1]。
Anti-Mouse CD3ε Antibody (145-2C11) (1 μg/mL，48 小时) 抑制脾细胞和胰腺淋巴结细胞 (pLNs) 中促炎细胞因子的产生，并增加抗炎细胞因子的生产[1]。
Anti-Mouse CD3ε Antibody (145-2C11) (5 μg/mL，2 小时) 诱导巨噬细胞吞噬 T 细胞[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CD3ε Antibody (145-2C11) 相关抗体:

Cell Proliferation Assay[1]

Cell Line: Splenic cells
Concentration: 0.04, 0.02 and 1 μg/mL
Incubation Time: 72 h
Result: Significantly inhibited the proliferation of splenic cells at 1 μg/mL.

ELISA Assay[1]

Cell Line: Splenic cells and pLNs
Concentration: 1 μg/mL
Incubation Time: 48 h
Result: Increased the levels of TGF-β and IL-10 and decreased the levels of IFN-γ and IL-17.
体内研究
(In Vivo)

Anti-Mouse CD3ε Antibody (145-2C11) (10 μg，口服或鼻腔给药，前 5 天每天一次，然后每周一次直到 20 周龄) 显著降低了雌性 NOD 小鼠的糖尿病发病率[1]。
Anti-Mouse CD3ε Antibody (145-2C11) (50 μg，口服，每天一次，持续 5 天) 可降低效应 T 细胞的致病性，改善雌性 NOD-huCD3ε 小鼠的 T 细胞功能[1]。
Anti-Mouse CD3ε Antibody (145-2C11) (3 mg/kg，腹腔注射，每周一次，持续 20 周) 延长了狼疮模型雌性 BWF1 小鼠的存活期[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NOD mice (6 weeks)[1]
Dosage: 10 μg
Administration: Oral administration (p.o.) or nasal administration, once daily for the first 5 days and then once per week until 20 weeks of age
Result: Significantly reduced the incidence rate of diabetes to 50 %.
Reduced pancreatic islet infiltration and inflammation.
Animal Model: Female NOD-huCD3ε mice (12 weeks)[1]
Dosage: 50 μg
Administration: Oral administration (p.o.), once daily, for 5 days
Result: Reduced the pathogenicity of effector T cells and enhanced the function of regulatory T cells.
Reduced the incidence rate of diabetes.
Animal Model: Female BWF1 mice (20 weeks) with a lupus model[2]
Dosage: 3 mg/kg
Administration: Intraperitoneal injection (i.p.), once weekly for 20 weeks
Result: Significantly reduced proteinuria in mice.
Extended the survival period of mice.
基因 ID

12501  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 95.00%

COA (268 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse CD3ε Antibody (145-2C11) 相关分类

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  • 稀释计算器

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质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD3ε Antibody (145-2C11)CD3Cluster of differentiation 3CD3εT celldiabeteslupusInhibitorinhibitorinhibit

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