Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) 

Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) is a rat-derived anti-LPAM-1/Integrin α4β7 IgG2a, κ type antibody inhibitor. Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) specifically reacts with both chains of the α4β7 heterodimer and blocks the adhesion to immobilized mucosal addressin cell adhesion molecule-1 (MAdCAM-1). Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) suppresses the proliferation and cytokine secretion of CD8+ T cells. Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) decreases Peyer’s patches and follicular B cells in mice. Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) can be used for the researches of inflammation, such as ulcerative colitis^[1][2][3][4].

Rat IgG2a kappa

Rat IgG2a kappa, Isotype Control

Mouse

LPAM-1/Integrin α4β7

Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) (10 μg/mL, 10 mins) 可阻断 FDCP 混合细胞与固定化黏膜地址素细胞黏附分子-1 (MAdCAM-1) 的黏附^[1]。
Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) (100 μg/mL, 72 h) 可抑制 CD8 阳性 T 细胞的增殖和细胞因子分泌^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) (2 μg per 106 cells，注射前至少 30 分钟给药) 可减少 E 选择素缺陷 (E-/-) 小鼠模型中造血祖细胞 (HPCs) 向骨髓的归巢^[1]。
Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) (500 μg，腹腔注射，从第 8 天至第 10 天每天给药) 不会在同种异体 BALB/c x C57BL/6J 妊娠中引起异常妊娠^[2]。
Anti-Mouse LPAM-1/Integrin α4β7 Antibody (DATK32) (腹腔注射，单剂量) 可减少 C56B6 野生型小鼠的派尔集合淋巴结和滤泡 B 细胞^[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

16401  [NCBI]

Q00651

ELISA, FACS, Functional assay, Research in vivo

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

液体

Colorless to light yellow

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Katayama Y, et al. Integrin alpha4beta7 and its counterreceptor MAdCAM-1 contribute to hematopoietic progenitor recruitment into bone marrow following transplantation. Blood. 2004 Oct 1;104(7):2020-6.  [Content Brief]

  [2]. Fernekorn U, et al. Functional involvement of P-selectin and MAdCAM-1 in the recruitment of alpha4beta7-integrin-expressing monocyte-like cells to the pregnant mouse uterus. Eur J Immunol. 2004 Dec;34(12):3423-33.  [Content Brief]

  [3]. Su Z, Bian L, et al. Gut-tropic α4β7+CD8+ T cells contribute to pancreatic β cell destruction in type 1 diabetes. Front Immunol. 2025 Jul 10;16:1623428.  [Content Brief]

  [4]. P Canales-Herrerias, et al. P061 Response to anti-α4β7 therapy in Ulcerative colitis is associated with lymphoid aggregate attrition through impaired recruitment of naïve lymphocytes, Journal of Crohn's and Colitis, Volume 17, Issue Supplement_1, February 2023, Pages i227–i228.