2. Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation
  3. Glutathione Peroxidase STING
  4. Anti-Mouse myeloperoxidase/MPO Antibody (6G4)

Anti-Mouse myeloperoxidase/MPO Antibody (6G4) 

目录号: HY-P990181 纯度: 95.00%
COA 技术支持

Anti-Mouse myeloperoxidase/MPO Antibody (6G4) 是一种抗小鼠 myeloperoxidase/MPO 单克隆抗体。Anti-Mouse myeloperoxidase/MPO Antibody (6G4) 可以激活 cGAS/STING 通路。Anti-Mouse myeloperoxidase/MPO Antibody (6G4) 诱导小鼠急性和慢性肾损伤。Anti-Mouse myeloperoxidase/MPO Antibody (6G4) 通常用于构建炎症疾病模型，如抗中性粒细胞胞浆抗体 (ANCA) 相关血管炎 (AAV)。

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Anti-Mouse myeloperoxidase/MPO Antibody (6G4)

Anti-Mouse myeloperoxidase/MPO Antibody (6G4) Chemical Structure

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1 mg ￥2200
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Anti-Mouse myeloperoxidase/MPO Antibody (6G4) 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse myeloperoxidase/MPO Antibody (6G4) is an anti-mouse myeloperoxidase/MPO IgG2c monoclonal antibody. Anti-Mouse myeloperoxidase/MPO Antibody (6G4) can activate the cGAS/STING pathway. Anti-Mouse myeloperoxidase/MPO Antibody (6G4) induces acute and chronic kidney injury in mice. Anti-Mouse myeloperoxidase/MPO Antibody (6G4) is often used in the construction of inflammation conditions models such as anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV)[1][2].

同型

Mouse IgG2c kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

myeloperoxidase/MPO
体外研究
(In Vitro)

Anti-Mouse myeloperoxidase/MPO Antibody (6G4) (5 μg/mL, 30 分钟) 可以与 C57BL/6J 小鼠骨髓来源的活化中性粒细胞释放的细胞外 DNA 结合，形成 DNA/MPO/IgG 免疫复合物[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse myeloperoxidase/MPO Antibody (6G4) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse myeloperoxidase/MPO Antibody (6G4) (0.75 mg，腹腔注射，单次剂量，抗大鼠肾小球基底膜血清处理后第 5 天) 在雌性 C57BL/6J 小鼠中成功模拟了抗中性粒细胞胞浆抗体 (ANCA) 相关性血管炎 (AAV)[1]。
Anti-Mouse myeloperoxidase/MPO Antibody (6G4) (1 mg，腹腔注射，单剂量) 在雌性 C57BL/6J 小鼠中成功建立了肺血管炎模型[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C57BL/6J mice (8-10 weeks)[1]
Dosage: 0.75 mg, combined with anti-rat glomerular basement membrane serum (100 μL, i.v., on day 0), anti-MPO mAb (6D1) (0.75 mg) and LPS (0.5 μg/g) (HY-D1056)
Administration: Intraperitoneal injection (i.p.), single dose on day 5
Result: Caused 70% of glomerular necrosis or crescent formation during the acute phase.
Caused 70% of glomerular scarring during the chronic phase.
Increased the infiltration of neutrophils and macrophages in the acute phase and T cells in the chronic phase.
Significantly upregulated inflammatory factors and ECM molecules.
Animal Model: Female C57BL/6J mice (8-12 weeks)[2]
Dosage: 1 mg, combined with fMLP (10 μg, intratracheal injection (i.t.)) (HY-P0224), LPS (10 μg, intratracheal injection (i.t.)) (HY-D1056) and anti-MPO mAb (6D1) (0.5 mg)
Administration: Intraperitoneal injection (i.p.), single dose
Result: Relied on the cGAS/STING/IFN-I pathway to synergistically induce severe pulmonary hemorrhage and inflammation with bacterial ligands.
基因 ID

17523  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 95.00%

COA (268 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse myeloperoxidase/MPO Antibody (6G4) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse myeloperoxidase/MPO Antibody (6G4)Glutathione PeroxidaseSTINGStimulator of Interferon GenesTMEM173MITAERISMPYSmyeloperoxidaseMPOcGAS/STINGinflammationAAVInhibitorinhibitorinhibit

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