2. Neuronal Signaling Stem Cell/Wnt Anti-infection
  3. Notch Influenza Virus
  4. Anti-Mouse Notch4 Antibody (HMN4-14)

Anti-Mouse Notch4 Antibody (HMN4-14) 

目录号: HY-P990177
技术支持

Anti-Mouse Notch4 Antibody (HMN4-14) 是一种抗小鼠 Notch4 IgG 单克隆抗体。Anti-Mouse Notch4 Antibody (HMN4-14) 通过恢复双特异性蛋白的表达来减少炎症。Anti-Mouse Notch4 Antibody (HMN4-14) 可以抑制 Th2/Th17 细胞分化，改善 Treg 细胞功能。Anti-Mouse Notch4 Antibody (HMN4-14) 可用于研究炎症疾病，如病毒性肺炎和气道炎症。

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Anti-Mouse Notch4 Antibody (HMN4-14)

Anti-Mouse Notch4 Antibody (HMN4-14) Chemical Structure

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Anti-Mouse Notch4 Antibody (HMN4-14) 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse Notch4 Antibody (HMN4-14) is an anti-mouse Notch4 IgG monoclonal antibody. Anti-Mouse Notch4 Antibody (HMN4-14) reduces inflammation by restoring the expression of bispecific proteins. Anti-Mouse Notch4 Antibody (HMN4-14) can inhibit Th2/Th17 cell differentiation and improve Treg cell function. Anti-Mouse Notch4 Antibody (HMN4-14) can be used for research on inflammation conditions such as viral pneumonia and airway inflammation[1][2].

同型

Armenian hamster IgG
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

Notch4
体外研究
(In Vitro)

Anti-Mouse Notch4 Antibody (HMN4-14) (10μg/mL，72 小时) 抑制巨噬细胞的 M1 极化并促进 M2 极化[1]。
Anti-Mouse Notch4 Antibody (HMN4-14) (10 μg/mL，72小时) 显著增加 Treg 细胞中双特异性蛋白的表达[1]。
Anti-Mouse Notch4 Antibody (HMN4-14) (10 μg/mL，72 小时) 显著抑制超细颗粒 UFP 诱导的 Th2/Th17 细胞分化，并减少 Treg 细胞向 Th 样细胞的转化[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse Notch4 Antibody (HMN4-14) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse Notch4 Antibody (HMN4-14) (10 μg，腹腔注射，在第 4 天和第 7 天) 缓解了 H1N1 病毒感染模型中 Foxp3YFPcre 小鼠的肺部炎症[1]。
Anti-Mouse Notch4 Antibody (HMN4-14) (150 µg，腹腔注射，每日一次，持续 3 天) 显著减轻了 OVA (HY-P0286) 诱导的气道炎症模型中 Il4raR576 小鼠的气道炎症[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 40000 PFU H1N1 virus injected Foxp3YFPcre mice[1]
Dosage: 10 μg
Administration: Intraperitoneal injection (i.p.), on day 4 and 7
Result: Significantly reduced mortality rate.
Reduced lung inflammation and cytokine storm.
Animal Model: OVA (100 μg) induced Il4raR576 mice[2]
Dosage: 150 µg
Administration: Intraperitoneal injection (i.p.), once daily, for 3 days
Result: Reduced inflammation score.
Reduced eosinophil infiltration.
Reduced Th2/Th17 cell responses and IgE levels.
基因 ID

18132  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Anti-Mouse Notch4 Antibody (HMN4-14) 相关分类

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse Notch4 Antibody (HMN4-14)NotchInfluenza VirusNotch4TregTh2/Th17H1N1airway inflammationpneumoniaInhibitorinhibitorinhibit

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