2. Immunology/Inflammation
  3. Osteopontin
  4. Anti-Mouse osteopontin/SPP1 Antibody (103D6)

Anti-Mouse osteopontin/SPP1 Antibody (103D6) 

目录号: HY-P990116 纯度: 95.00%
COA 技术支持

Anti-Mouse osteopontin/SPP1 Antibody (103D6) 是一种源自小鼠的抗小鼠 osteopontin/SPP1 IgG2c κ 型抗体抑制剂。Anti-Mouse osteopontin/SPP1 Antibody (103D6) 可以增强细胞毒性 T 淋巴细胞的裂解活性并抑制结肠肿瘤生长。Anti-Mouse osteopontin/SPP1 Antibody (103D6) 可以改善胆总管结扎 (CBDL) 诱导的原发性硬化性胆管炎模型小鼠的肝损伤。

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Anti-Mouse osteopontin/SPP1 Antibody (103D6)

Anti-Mouse osteopontin/SPP1 Antibody (103D6) Chemical Structure

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Anti-Mouse osteopontin/SPP1 Antibody (103D6) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse osteopontin/SPP1 Antibody (103D6) is a mouse-derived anti-mouse osteopontin/SPP1 IgG2c κ type antibody inhibitor. Anti-Mouse osteopontin/SPP1 Antibody (103D6) increases cytotoxic T lymphocyte lytic activity and suppresses colon tumor growth. Anti-Mouse osteopontin/SPP1 Antibody (103D6) ameliorates liver injury in common bile duct ligation (CBDL)-induced primary sclerosing cholangitis mice models[1][2].

同型

Mouse IgG2c kappa
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

osteopontin/SPP1
体外研究
(In Vitro)

Anti-Mouse osteopontin/SPP1 Antibody (103D6) (24 h) 显著增加肿瘤特异性细胞毒性 T 淋巴细胞 (CTL) 在裂解 CT26 肿瘤细胞时的裂解活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse osteopontin/SPP1 Antibody (103D6) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse osteopontin/SPP1 Antibody (103D6) (200 μg/mouse，皮下注射，每 3 天一次，共 14 天) 可抑制结肠癌小鼠模型中 CT26 肿瘤的生长[1]。
Anti-Mouse osteopontin/SPP1 Antibody (103D6) (200 μg/mouse，在 CBDL 手术前以及术后第 2 、5、7 天给药) 可改善胆总管结扎 (CBDL) 诱导的原发性硬化性胆管炎小鼠模型中的肝损伤[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Colon tumor mice models injected with CT 26 cells (BALB/c, 2-3 months)[1]
Dosage: 200 μg/mouse
Administration: Subcutaneously injection, every 3 days for 14 days
Result: Suppressed CT26 tumor growth.
Animal Model: Common bile duct ligation (CBDL)-induced primary sclerosing cholangitis mice models (C57BL6/J, male, 8 weeks)[2]
Dosage: 200 μg/mouse
Administration: Before CBDL operation and at day 2, day 5 and day 7 following CBDL
Result: Showed lower serum alanine transaminase.
Had less ductular reaction, necrosis and fibrosis.
Decreased expression levels of inflammatoryand fibrotic markers.
基因 ID

20750  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 95.00%

COA (268 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse osteopontin/SPP1 Antibody (103D6) 相关分类

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse osteopontin/SPP1 Antibody (103D6)OsteopontinSecreted Phosphoprotein 1SPP1Cytotoxic T lymphocyteColon tumorCBDLInhibitorinhibitorinhibit

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