2. Apoptosis
  3. TNF Receptor
  4. Anti-Mouse/Rat/Rabbit TNF alpha Antibody (TN3-19.12)

Anti-Mouse/Rat/Rabbit TNF alpha Antibody (TN3-19.12) 

目录号: HY-P99148 纯度: 95.00%
COA 技术支持

Anti-Mouse TNF alpha Antibody (TN3-19.12) 是一种源自亚美尼亚仓鼠宿主的抗小鼠 TNF alpha 的 IgG 抗体抑制剂。Anti-Mouse TNF alpha Antibody (TN3-19.12) 可中和上清液中从 LNC-8 细胞获得的细胞毒性。Anti-Mouse TNF alpha Antibody (TN3-19.12) 可减轻 LNC-8 细胞异种移植小鼠模型中实验性自身免疫性脑脊髓炎 (EAE) 的症状和严重程度。Anti-Mouse TNF alpha Antibody (TN3-19.12) 可预防非肥胖糖尿病 (NOD) 小鼠发生糖尿病。Anti-Mouse TNF alpha Antibody (TN3-19.12) 在 CD2F1 小鼠中显示出明显的放射增敏作用。

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Anti-Mouse/Rat/Rabbit TNF alpha Antibody (TN3-19.12) 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Mouse TNF alpha Antibody (TN3-19.12) is an anti-mouse TNF alpha IgG antibody inhibitor derived from host Armenian Hamster. Anti-Mouse TNF alpha Antibody (TN3-19.12) neutralizes cytotoxic activity in supernatants obtained from LNC-8 cells. Anti-Mouse TNF alpha Antibody (TN3-19.12) reduces the symptoms and severity of EAE (experimental allergic encephalomyelitis) in LNC-8 cells xenograft mice models. Anti-Mouse TNF alpha Antibody (TN3-19.12) prevents diabetes in NOD mice. Anti-Mouse TNF alpha Antibody (TN3-19.12) shows apparent radiosensitizing effect in CD2F1 mice[1][2][3].

同型

Armenian Hamster IgG
推荐同型对照抗体
反应种属

Mouse
IC50 & Target

TNF alpha
体外研究
(In Vitro)

Anti-Mouse TNF alpha Antibody (TN3-19.12) (850 ng, 1 h) 可中和上清液中从 LNC-8 细胞获得的细胞毒性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse/Rat/Rabbit TNF alpha Antibody (TN3-19.12) 相关抗体:
体内研究
(In Vivo)

Anti-Mouse TNF alpha Antibody (TN3-19.12) (0.3-1 mg，腹腔注射，单剂量) 可减轻 LNC-8 细胞异种移植小鼠模型中实验性自身免疫性脑脊髓炎 (EAE) 的症状和严重程度[1]。

Anti-Mouse TNF alpha Antibody (TN3-19.12) (20 μg/g or 100 μg/injection，腹腔注射，隔天 1 次，持续 21-24 天) 可预防非肥胖糖尿病小鼠 (0-4 周龄) 发生糖尿病[2]。

Anti-Mouse TNF alpha Antibody (TN3-19.12) (50-100 μg，腹腔注射，单剂量) 可降低受辐照的 CD2F1 小鼠的存活率[3]。

Anti-Mouse TNF alpha Antibody (TN3-19.12) (200 μg，腹腔注射，给 LPS (HY-D1056) 前 20 h) 可降低 CD2F1 小鼠中脂多糖诱导的辐射防护作用[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice injected with LNC-8 cells intraperitoneally[1]
Dosage: 0.3 mg
Administration: Intraperitoneal injection
Result: Resulted in a dramatic reduction in the symptoms and severity of EAE (experimental allergic encephalomyelitis).
Alleviated meningeal infiltration.
Animal Model: Mice injected with LNC-8 cells intravenously[1]
Dosage: 1 mg
Administration: Intraperitoneal injection
Result: Reduced the symptoms and severity of EAE.
Reduced the incidence of disease from 89% in the PBS to 20%.
Animal Model: Newborn female NOD mice[2]
Dosage: 20 μg/g
Administration: Intraperitoneally every other day for 24 days
Result: None of mice developed diabetes even after 30 week of age.
Had no significant effect on mouse development and growth, or mortality.
Had no dramatic influence on the development of lymphoid tissues.
Did not potentiate the ability to respond to GAD67, GAD65, CPH, peripherin, and HSP60 at 10 week of age.
Enhanced responses to HEL and OVA.
Inhibited insulitis (only 27% of mice developed a low or moderate degree of insulitis compared to PBS-treated of 100%).
Animal Model: 2-week-old female NOD mice[2]
Dosage: 20 μg/g
Administration: Intraperitoneally every other day for 3 weeks
Result: None of mice developed diabetes even after 34 week of age.
Animal Model: 4-week-old female NOD mice[2]
Dosage: 100 μg/injection
Administration: Intraperitoneally every other day for 3 weeks
Result: Partly prevented disease (about 50%).
Animal Model: Irradiated CD2F1 mice (male, 8-10 week) [3]
Dosage: 100 μg 20 h before irradiation or at 50 μg 1 h after irradiation
Administration: Intraperitoneal injection
Result: Reduced survival of irradiated CD2F1 mice.
基因 ID

7124  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
  • Immobilized TNF-alpha/TNFSF2 Protein, Mouse (His, HY-P7417) can bind Anti-Mouse/Rat/Rabbit TNF alpha Antibody (TN3-19.12). The EC50 for this effect is 54.46 ng/mL.
纯度 & 产品资料

纯度: ≥95.0%

COA (268 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Mouse/Rat/Rabbit TNF alpha Antibody (TN3-19.12) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse/Rat/Rabbit TNF alpha Antibody (TN3-19.12)TNF ReceptorTumor Necrosis Factor ReceptorTNFRTNFLNC-8EAEDiabetesCD2F1Inhibitorinhibitorinhibit

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Anti-Mouse/Rat/Rabbit TNF alpha Antibody (TN3-19.12)
目录号：
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