2. Anti-infection Apoptosis Cell Cycle/DNA Damage
  3. Antibiotic Apoptosis DNA/RNA Synthesis
  4. Antibiotic DC 81

Antibiotic DC 81  (Synonyms: DC 81)

目录号: HY-107767
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摩尔计算器

Antibiotic DC 81 (DC 81) 是一种由链霉菌种产生的抗肿瘤抗生素 (antitumor antibiotic)，是一种吡咯[2,1 -c][1,4]苯二氮平 (PBD)。Antibiotic DC 81 是核酸合成的有效抑制剂。Antibiotic DC 81 可以识别和结合特定的 DNA 序列，形成不稳定的共价加合物。

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Antibiotic DC 81 Chemical Structure

Antibiotic DC 81 Chemical Structure

CAS No. : 81307-24-6

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Antibiotic DC 81 相关抗体

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antibiotic DC 81 (DC 81), an antitumor antibiotic produced by Streptomyces species, is a PBD (pyrrolo[2,1-c][1,4]benzodiazepine). Antibiotic DC 81 is potent inhibitor of nucleic acid synthesis. Antibiotic DC 81 can recognize and bind to specific sequences of DNA and form a labile covalent adduct[1][2].

体外研究
(In Vitro)

Antibiotic DC 81 shows cytotoxicity against human melanoma cell lines B16, A375, A2058, and RPMI7951, with IC50 values of 4.4 μM, 18.5 μM, 31.0 μM, and 41.5 μM, respectively[1][2].
Antibiotic DC 81 exhibits its biological activity by covalently binding to the N2 of guanine in the minor groove of DNA, via the electrophilic carbinolamine functionality at N10-C11[1].
Antibiotic DC 81 (4 μM, 24 h) induces mitochondria dependent apoptosis[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antibiotic DC 81 相关抗体:

Apoptosis Analysis[2]

Cell Line: B16 melanoma cells
Concentration: 4 μM
Incubation Time: 24 h
Result: Induced mitochondria dependent apoptosis.
体内研究
(In Vivo)

Antibiotic DC 81 (0-10 mg/kg, i.p., at day 4, 7, 10, 13 after tumor cell injection) decreases the tumor burden in tumor-bearing mice, but the Antibiotic DC 81 at 10 mg/kg impairs cardiac muscle enzyme and liver function significantly[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C57BL/6 mice (8-12 weeks old, B16 cells were injected into the tail veins of mice)[2]
Dosage: 0.1, 1, 10 mg/kg
Administration: i.p., at day 4, 7, 10, 13 after tumor cell injection
Result: Substantially decreased the tumor burden by 20% at 1 mg/kg. DC-81 at 10 mg/kg induced an 8-10-fold increase of GPT and a 6-8-fold increase in CPK, which indicated severe impaired liver function and muscle damage. Did not impair significant renal function as demonstrated by serum creatinine.
分子量

246.26

Formula

C13H14N2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antibiotic DC 81 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antibiotic DC 8181307-24-6DC 81Antibiotic DC81Antibiotic DC-81DC81DC-81AntibioticApoptosisDNA/RNA SynthesisA2058A375RPMI7951Hs695Tpyrrolo[21-c][14]benzodiazepinesPBDsindole carboxylate moietymelanomaInhibitorinhibitorinhibit

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