2. Anti-infection Apoptosis Cell Cycle/DNA Damage
  3. Antibiotic Apoptosis DNA/RNA Synthesis
  4. Antibiotic DC 81

Antibiotic DC 81 (DC 81) 是一种由链霉菌种产生的抗肿瘤抗生素 (antitumor antibiotic)，是一种吡咯[2,1 -c][1,4]苯二氮平 (PBD)。Antibiotic DC 81 是核酸合成的有效抑制剂。Antibiotic DC 81 可以识别和结合特定的 DNA 序列，形成不稳定的共价加合物。

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Antibiotic DC 81

Antibiotic DC 81 Chemical Structure

CAS No. : 81307-24-6

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Antibiotic DC 81 相关抗体

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antibiotic DC 81 (DC 81), an antitumor antibiotic produced by Streptomyces species, is a PBD (pyrrolo[2,1-c][1,4]benzodiazepine). Antibiotic DC 81 is potent inhibitor of nucleic acid synthesis. Antibiotic DC 81 can recognize and bind to specific sequences of DNA and form a labile covalent adduct[1][2].

体外研究
(In Vitro)

Antibiotic DC 81 对人黑素瘤细胞株 B16、A375、A2058 和 RPMI7951 具有细胞毒性，IC50 值分别为 4.4 μM、18.5 μM、31.0 μM 和 41.5 μM[1][2]。
Antibiotic DC 81 通过在 N10-C11 处的亲电氨基醇胺功能与 DNA 小槽中的鸟嘌呤 N2 共价结合，显示其生物活性[1]。
Antibiotic DC 81 (4 μM, 24 h) 诱导线粒体依赖性凋亡[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antibiotic DC 81 相关抗体:

Apoptosis Analysis[2]

Cell Line: B16 melanoma cells
Concentration: 4 μM
Incubation Time: 24 h
Result: Induced mitochondria dependent apoptosis.
体内研究
(In Vivo)

Antibiotic DC 81 (0-10 mg/kg，腹腔注射，注射肿瘤细胞后第4、7、10、13天)可降低荷瘤小鼠的肿瘤负担，但 10 mg/kg 剂量的 Antibiotic DC 81 会显著损害心肌酶和肝功能[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C57BL/6 mice (8-12 weeks old, B16 cells were injected into the tail veins of mice)[2]
Dosage: 0.1, 1, 10 mg/kg
Administration: i.p., at day 4, 7, 10, 13 after tumor cell injection
Result: Substantially decreased the tumor burden by 20% at 1 mg/kg. DC-81 at 10 mg/kg induced an 8-10-fold increase of GPT and a 6-8-fold increase in CPK, which indicated severe impaired liver function and muscle damage. Did not impair significant renal function as demonstrated by serum creatinine.
分子量

246.26

Formula

C13H14N2O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antibiotic DC 81 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antibiotic DC 8181307-24-6DC 81Antibiotic DC81Antibiotic DC-81DC81DC-81AntibioticApoptosisDNA/RNA SynthesisA2058A375RPMI7951Hs695Tpyrrolo[21-c][14]benzodiazepinesPBDsindole carboxylate moietymelanomaInhibitorinhibitorinhibit

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产品名称：
Antibiotic DC 81
目录号：
HY-107767
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