Antibiotic DC 81 (Synonyms: DC 81)

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Antibiotic DC 81 (DC 81) 是一种由链霉菌种产生的抗肿瘤抗生素 (antitumor antibiotic)，是一种吡咯[2,1 -c][1,4]苯二氮平 (PBD)。Antibiotic DC 81 是核酸合成的有效抑制剂。Antibiotic DC 81 可以识别和结合特定的 DNA 序列，形成不稳定的共价加合物。

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Antibiotic DC 81 Chemical Structure

CAS No. : 81307-24-6

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生物活性
纯度 & 产品资料
参考文献

生物活性

Antibiotic DC 81 (DC 81), an antitumor antibiotic produced by Streptomyces species, is a PBD (pyrrolo[2,1-c][1,4]benzodiazepine). Antibiotic DC 81 is potent inhibitor of nucleic acid synthesis. Antibiotic DC 81 can recognize and bind to specific sequences of DNA and form a labile covalent adduct^[1]^[2].

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
A-431	IC₅₀	1.65 μM Compound: I, DC-81	Anticancer activity against human A431 cells after 48 hrs by MTT assay Anticancer activity against human A431 cells after 48 hrs by MTT assay	[PMID: 22209733]
A2780	GI₅₀	0.14 μM Compound: 1, DC-81	Growth inhibition of human A2780 cells Growth inhibition of human A2780 cells	10.1039/C1MD00072A
A2780	GI₅₀	0.14 μM Compound: 1, DC-81	Cytotoxicity against human A2780 cells after 48 hrs by SRB assay Cytotoxicity against human A2780 cells after 48 hrs by SRB assay	[PMID: 20444601]
A2780	GI₅₀	0.14 μM Compound: 1, DC-81	Cytotoxicity against human A2780 cells after 24 hrs by WST-1 assay Cytotoxicity against human A2780 cells after 24 hrs by WST-1 assay	[PMID: 20732817]
A2780	GI₅₀	0.14 μM Compound: 1, DC-81	Anticancer activity against human A2780 cells by SRB method Anticancer activity against human A2780 cells by SRB method	[PMID: 21676506]
A2780	GI₅₀	0.14 μM Compound: 2, DC-81	Cytotoxicity against human A2780 cells by sulforhodamine B method Cytotoxicity against human A2780 cells by sulforhodamine B method	[PMID: 21459581]
A2780	GI₅₀	0.14 μM Compound: 3, DC-81	Growth inhibition of human A2780 cells after 48 hrs by SRB assay Growth inhibition of human A2780 cells after 48 hrs by SRB assay	[PMID: 20031423]
A2780	GI₅₀	0.14 μM Compound: 3, DC-81	Cytotoxicity against human A2780 cells after 48 hrs by SRB assay Cytotoxicity against human A2780 cells after 48 hrs by SRB assay	[PMID: 20673627]
A2780	GI₅₀	0.14 μM Compound: 3, DC-81	Anticancer activity against human A2780 cells by SRB method Anticancer activity against human A2780 cells by SRB method	[PMID: 22104151]
A2780	GI₅₀	0.14 μM Compound: 4, DC-81	Anticancer activity against human A2780 cells after 48 hrs by SRB assay Anticancer activity against human A2780 cells after 48 hrs by SRB assay	[PMID: 20557981]
A2780	GI₅₀	0.14 μM Compound: DC-81	Growth inhibition of human A2780 cells by SRB method Growth inhibition of human A2780 cells by SRB method	[PMID: 18207392]
A2780	GI₅₀	0.14 μM Compound: DC-81	Cytotoxicity against human A2780 cells after 48 hrs by SRB assay Cytotoxicity against human A2780 cells after 48 hrs by SRB assay	[PMID: 20554354]
A549	GI₅₀	0.16 μM Compound: 1, DC-81	Growth inhibition of human A549 cells Growth inhibition of human A549 cells	10.1039/C1MD00072A
A549	GI₅₀	0.16 μM Compound: 1, DC-81	Cytotoxicity against human A549 cells after 48 hrs by SRB assay Cytotoxicity against human A549 cells after 48 hrs by SRB assay	[PMID: 20444601]
A549	GI₅₀	0.16 μM Compound: 1, DC-81	Cytotoxicity against human A549 cells after 24 hrs by WST-1 assay Cytotoxicity against human A549 cells after 24 hrs by WST-1 assay	[PMID: 20732817]
A549	GI₅₀	0.16 μM Compound: 1, DC-81	Anticancer activity against human A549 cells by SRB method Anticancer activity against human A549 cells by SRB method	[PMID: 21676506]
A549	GI₅₀	0.16 μM Compound: 2, DC-81	Cytotoxicity against human A549 cells by sulforhodamine B method Cytotoxicity against human A549 cells by sulforhodamine B method	[PMID: 21459581]
A549	GI₅₀	0.16 μM Compound: 3, DC-81	Growth inhibition of human A549 cells after 48 hrs by SRB assay Growth inhibition of human A549 cells after 48 hrs by SRB assay	[PMID: 20031423]
A549	GI₅₀	0.16 μM Compound: 3, DC-81	Cytotoxicity against human A549 cells after 48 hrs by SRB assay Cytotoxicity against human A549 cells after 48 hrs by SRB assay	[PMID: 20673627]
A549	GI₅₀	0.16 μM Compound: 3, DC-81	Anticancer activity against human A549 cells by SRB method Anticancer activity against human A549 cells by SRB method	[PMID: 22104151]
A549	GI₅₀	0.16 μM Compound: DC-81	Growth inhibition of human A549 cells by SRB method Growth inhibition of human A549 cells by SRB method	[PMID: 18207392]
A549	GI₅₀	0.16 μM Compound: DC-81	Cytotoxicity against human A549 cells after 48 hrs by SRB assay Cytotoxicity against human A549 cells after 48 hrs by SRB assay	[PMID: 20554354]
A549	IC₅₀	1.11 μM Compound: I, DC-81	Anticancer activity against human A549 cells after 48 hrs by MTT assay Anticancer activity against human A549 cells after 48 hrs by MTT assay	[PMID: 22209733]
CH1	IC₅₀	0.1 μM Compound: 3	In vitro cytotoxicity against ovarian carcinoma cell line CH1. In vitro cytotoxicity against ovarian carcinoma cell line CH1.	[PMID: 10514273]
CH1	IC₅₀	0.1 μM Compound: 5	Tested for cytotoxicity against CH1 human ovarian cells Tested for cytotoxicity against CH1 human ovarian cells	[PMID: 10354403]
CHO-AA8	IC₅₀	2000 nM Compound: 31 (DC-81)	In vitro cellular toxicity against chinese hamster AA8 cell line after 4 hr of compound exposure In vitro cellular toxicity against chinese hamster AA8 cell line after 4 hr of compound exposure	[PMID: 12747786]
COLO 205	GI₅₀	0.11 μM Compound: 1, DC-81	Growth inhibition of human COLO205 cells Growth inhibition of human COLO205 cells	10.1039/C1MD00072A
COLO 205	GI₅₀	0.11 μM Compound: 1, DC-81	Cytotoxicity against human COLO205 cells after 48 hrs by SRB assay Cytotoxicity against human COLO205 cells after 48 hrs by SRB assay	[PMID: 20444601]
COLO 205	GI₅₀	0.11 μM Compound: 1, DC-81	Cytotoxicity against human COLO205 cells after 24 hrs by WST-1 assay Cytotoxicity against human COLO205 cells after 24 hrs by WST-1 assay	[PMID: 20732817]
COLO 205	GI₅₀	0.11 μM Compound: 1, DC-81	Anticancer activity against human COLO205 cells by SRB method Anticancer activity against human COLO205 cells by SRB method	[PMID: 21676506]
COLO 205	GI₅₀	0.11 μM Compound: 2, DC-81	Cytotoxicity against human COLO205 cells by sulforhodamine B method Cytotoxicity against human COLO205 cells by sulforhodamine B method	[PMID: 21459581]
COLO 205	GI₅₀	0.11 μM Compound: 3, DC-81	Growth inhibition of human COLO205 cells after 48 hrs by SRB assay Growth inhibition of human COLO205 cells after 48 hrs by SRB assay	[PMID: 20031423]
COLO 205	GI₅₀	0.11 μM Compound: 3, DC-81	Cytotoxicity against human COLO205 cells after 48 hrs by SRB assay Cytotoxicity against human COLO205 cells after 48 hrs by SRB assay	[PMID: 20673627]
COLO 205	GI₅₀	0.11 μM Compound: 3, DC-81	Anticancer activity against human COLO205 cells by SRB method Anticancer activity against human COLO205 cells by SRB method	[PMID: 22104151]
COLO 205	GI₅₀	0.11 μM Compound: DC-81	Growth inhibition of human Colo205 cells by SRB method Growth inhibition of human Colo205 cells by SRB method	[PMID: 18207392]
COLO 205	GI₅₀	0.11 μM Compound: DC-81	Cytotoxicity against human COLO205 cells after 48 hrs by SRB assay Cytotoxicity against human COLO205 cells after 48 hrs by SRB assay	[PMID: 20554354]
COLO 205	IC₅₀	0.86 μM Compound: I, DC-81	Anticancer activity against human COLO205 cells after 48 hrs by MTT assay Anticancer activity against human COLO205 cells after 48 hrs by MTT assay	[PMID: 22209733]
EMT6	IC₅₀	1100 nM Compound: 31 (DC-81)	In vitro cellular toxicity against murine mammary carcinoma EMT6 cell line after 4 hr of compound exposure In vitro cellular toxicity against murine mammary carcinoma EMT6 cell line after 4 hr of compound exposure	[PMID: 12747786]
HOP-62	GI₅₀	0.15 μM Compound: 1, DC-81	Growth inhibition of human HOP62 cells Growth inhibition of human HOP62 cells	10.1039/C1MD00072A
HOP-62	GI₅₀	0.15 μM Compound: 1, DC-81	Cytotoxicity against human HOP62 cells after 48 hrs by SRB assay Cytotoxicity against human HOP62 cells after 48 hrs by SRB assay	[PMID: 20444601]
HOP-62	GI₅₀	0.15 μM Compound: 1, DC-81	Cytotoxicity against human HOP62 cells after 24 hrs by WST-1 assay Cytotoxicity against human HOP62 cells after 24 hrs by WST-1 assay	[PMID: 20732817]
HOP-62	GI₅₀	0.15 μM Compound: 1, DC-81	Anticancer activity against human HOP62 cells by SRB method Anticancer activity against human HOP62 cells by SRB method	[PMID: 21676506]
HOP-62	GI₅₀	0.15 μM Compound: 2, DC-81	Cytotoxicity against human HOP62 cells by sulforhodamine B method Cytotoxicity against human HOP62 cells by sulforhodamine B method	[PMID: 21459581]
HOP-62	GI₅₀	0.15 μM Compound: 3, DC-81	Growth inhibition of human HOP62 cells after 48 hrs by SRB assay Growth inhibition of human HOP62 cells after 48 hrs by SRB assay	[PMID: 20031423]
HOP-62	GI₅₀	0.15 μM Compound: 3, DC-81	Cytotoxicity against human HOP62 cells after 48 hrs by SRB assay Cytotoxicity against human HOP62 cells after 48 hrs by SRB assay	[PMID: 20673627]
HOP-62	GI₅₀	0.15 μM Compound: DC-81	Cytotoxicity against human HOP62 cells after 48 hrs by SRB assay Cytotoxicity against human HOP62 cells after 48 hrs by SRB assay	[PMID: 20554354]
HT-29	IC₅₀	30.19 μM Compound: 16b, DC-81	Cytotoxicity against human HT29 cells by MTT assay Cytotoxicity against human HT29 cells by MTT assay	[PMID: 18538566]
Jurkat	IC₅₀	2.2 μM Compound: 9, DC-81	Antiproliferative activity against human Jurkat cells Antiproliferative activity against human Jurkat cells	[PMID: 17081759]
K562	IC₅₀	1 μM Compound: 9, DC-81	Antiproliferative activity against human K562 cells Antiproliferative activity against human K562 cells	[PMID: 17081759]
KB	GI₅₀	0.17 μM Compound: 1, DC-81	Growth inhibition of human KB cells Growth inhibition of human KB cells	10.1039/C1MD00072A
KB	GI₅₀	0.17 μM Compound: 1, DC-81	Cytotoxicity against human KB cells after 48 hrs by SRB assay Cytotoxicity against human KB cells after 48 hrs by SRB assay	[PMID: 20444601]
KB	GI₅₀	0.17 μM Compound: 1, DC-81	Cytotoxicity against human KB cells after 24 hrs by WST-1 assay Cytotoxicity against human KB cells after 24 hrs by WST-1 assay	[PMID: 20732817]
KB	GI₅₀	0.17 μM Compound: 1, DC-81	Anticancer activity against human KB cells by SRB method Anticancer activity against human KB cells by SRB method	[PMID: 21676506]
KB	GI₅₀	0.17 μM Compound: 2, DC-81	Cytotoxicity against human KB cells by sulforhodamine B method Cytotoxicity against human KB cells by sulforhodamine B method	[PMID: 21459581]
KB	GI₅₀	0.17 μM Compound: 3, DC-81	Growth inhibition of human KB cells after 48 hrs by SRB assay Growth inhibition of human KB cells after 48 hrs by SRB assay	[PMID: 20031423]
KB	GI₅₀	0.17 μM Compound: 3, DC-81	Cytotoxicity against human KB cells after 48 hrs by SRB assay Cytotoxicity against human KB cells after 48 hrs by SRB assay	[PMID: 20673627]
KB	GI₅₀	0.17 μM Compound: 3, DC-81	Anticancer activity against human KB cells by SRB method Anticancer activity against human KB cells by SRB method	[PMID: 22104151]
KB	GI₅₀	0.17 μM Compound: 4, DC-81	Anticancer activity against human KB cells after 48 hrs by SRB assay Anticancer activity against human KB cells after 48 hrs by SRB assay	[PMID: 20557981]
KB	GI₅₀	0.17 μM Compound: DC-81	Growth inhibition of human KB cells by SRB method Growth inhibition of human KB cells by SRB method	[PMID: 18207392]
KB	GI₅₀	0.17 μM Compound: DC-81	Cytotoxicity against human KB cells after 48 hrs by SRB assay Cytotoxicity against human KB cells after 48 hrs by SRB assay	[PMID: 20554354]
L1210	IC₅₀	0.38 μM Compound: 5	Tested for cytotoxicity against L1210 Leukemia cell Tested for cytotoxicity against L1210 Leukemia cell	[PMID: 10354403]
L1210	IC₅₀	0.38 μM Compound: DC-81	In vitro cytotoxicity was evaluated in L1210 cell line In vitro cytotoxicity was evaluated in L1210 cell line	[PMID: 14505647]
L1210	IC₅₀	0.38 μM Compound: DC-81	In vitro cytotoxicity against leukemia L1210 cell line In vitro cytotoxicity against leukemia L1210 cell line	[PMID: 14698184]
L1210	IC₅₀	0.38 μM Compound: DC-81	Compound was tested for inhibitory activity against L1210 cell line Compound was tested for inhibitory activity against L1210 cell line	[PMID: 15225736]
L1210	IC₅₀	0.38 μM Compound: DC-81	In vitro cytotoxicity against mouse leukemia L1210 cell lines In vitro cytotoxicity against mouse leukemia L1210 cell lines	[PMID: 15341949]
L1210	IC₅₀	0.38 μM Compound: DC-81	Tested in vitro for inhibition after 48 hr exposure against murine leukemia cell line L1210 Tested in vitro for inhibition after 48 hr exposure against murine leukemia cell line L1210	[PMID: 7996544]
L1210	IC₅₀	0.38 μM Compound: DC-81, 2	Cytotoxicity against mouse L1210 cells Cytotoxicity against mouse L1210 cells	[PMID: 18378445]
MCF7	GI₅₀	0.17 μM Compound: 1, DC-81	Growth inhibition of human MCF7 cells Growth inhibition of human MCF7 cells	10.1039/C1MD00072A
MCF7	GI₅₀	0.17 μM Compound: 1, DC-81	Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 20444601]
MCF7	GI₅₀	0.17 μM Compound: 1, DC-81	Cytotoxicity against human MCF7 cells after 24 hrs by WST-1 assay Cytotoxicity against human MCF7 cells after 24 hrs by WST-1 assay	[PMID: 20732817]
MCF7	GI₅₀	0.17 μM Compound: 1, DC-81	Anticancer activity against human MCF7 cells by SRB method Anticancer activity against human MCF7 cells by SRB method	[PMID: 21676506]
MCF7	GI₅₀	0.17 μM Compound: 2, DC-81	Cytotoxicity against human MCF7 cells by sulforhodamine B method Cytotoxicity against human MCF7 cells by sulforhodamine B method	[PMID: 21459581]
MCF7	GI₅₀	0.17 μM Compound: 3, DC-81	Growth inhibition of human MCF7 cells after 48 hrs by SRB assay Growth inhibition of human MCF7 cells after 48 hrs by SRB assay	[PMID: 20031423]
MCF7	GI₅₀	0.17 μM Compound: 3, DC-81	Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 20673627]
MCF7	GI₅₀	0.17 μM Compound: 3, DC-81	Anticancer activity against human MCF7 cells by SRB method Anticancer activity against human MCF7 cells by SRB method	[PMID: 22104151]
MCF7	GI₅₀	0.17 μM Compound: DC-81	Growth inhibition of human MCF7 cells by SRB method Growth inhibition of human MCF7 cells by SRB method	[PMID: 18207392]
MCF7	GI₅₀	0.17 μM Compound: DC-81	Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay	[PMID: 20554354]
MCF7	IC₅₀	5 μM Compound: 1, DC-81	Cytotoxicity against human MCF7 cells assessed as reduction cell viability after 24 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction cell viability after 24 hrs by MTT assay	10.1039/C2MD20219K
PC-3	GI₅₀	0.2 μM Compound: 1, DC-81	Growth inhibition of human PC3 cells Growth inhibition of human PC3 cells	10.1039/C1MD00072A
PC-3	GI₅₀	0.2 μM Compound: 1, DC-81	Cytotoxicity against human PC3 cells after 48 hrs by SRB assay Cytotoxicity against human PC3 cells after 48 hrs by SRB assay	[PMID: 20444601]
PC-3	GI₅₀	0.2 μM Compound: 1, DC-81	Cytotoxicity against human PC3 cells after 24 hrs by WST-1 assay Cytotoxicity against human PC3 cells after 24 hrs by WST-1 assay	[PMID: 20732817]
PC-3	GI₅₀	0.2 μM Compound: 1, DC-81	Anticancer activity against human PC3 cells by SRB method Anticancer activity against human PC3 cells by SRB method	[PMID: 21676506]
PC-3	GI₅₀	0.2 μM Compound: 2, DC-81	Cytotoxicity against human PC3 cells by sulforhodamine B method Cytotoxicity against human PC3 cells by sulforhodamine B method	[PMID: 21459581]
PC-3	GI₅₀	0.2 μM Compound: 3, DC-81	Growth inhibition of human PC3 cells after 48 hrs by SRB assay Growth inhibition of human PC3 cells after 48 hrs by SRB assay	[PMID: 20031423]
PC-3	GI₅₀	0.2 μM Compound: 3, DC-81	Cytotoxicity against human PC3 cells after 48 hrs by SRB assay Cytotoxicity against human PC3 cells after 48 hrs by SRB assay	[PMID: 20673627]
PC-3	GI₅₀	0.2 μM Compound: DC-81	Growth inhibition of human PC3 cells by SRB method Growth inhibition of human PC3 cells by SRB method	[PMID: 18207392]
PC-3	GI₅₀	0.2 μM Compound: DC-81	Cytotoxicity against human PC3 cells after 48 hrs by SRB assay Cytotoxicity against human PC3 cells after 48 hrs by SRB assay	[PMID: 20554354]
PC-3	IC₅₀	1.19 μM Compound: I, DC-81	Anticancer activity against human PC3 cells after 48 hrs by MTT assay Anticancer activity against human PC3 cells after 48 hrs by MTT assay	[PMID: 22209733]
PC-6	IC₅₀	0.33 μM Compound: DC-81	In vitro cytotoxicity was evaluated in PC6 cell line In vitro cytotoxicity was evaluated in PC6 cell line	[PMID: 14505647]
PC-6	IC₅₀	0.33 μM Compound: DC-81	In vitro cytotoxicity against leukemia PC6 cell line In vitro cytotoxicity against leukemia PC6 cell line	[PMID: 14698184]
PC-6	IC₅₀	0.33 μM Compound: DC-81	Compound was tested for inhibitory activity against PC6 cell line Compound was tested for inhibitory activity against PC6 cell line	[PMID: 15225736]
PC-6	IC₅₀	0.33 μM Compound: DC-81	In vitro cytotoxicity against human lung cancer PC-6 cells lines In vitro cytotoxicity against human lung cancer PC-6 cells lines	[PMID: 15341949]
PC-6	IC₅₀	0.33 μM Compound: DC-81, 2	Cytotoxicity against human PC6 cells Cytotoxicity against human PC6 cells	[PMID: 18378445]
SK-OV-3	IC₅₀	1900 nM Compound: 31 (DC-81)	In vitro cellular toxicity against human ovarian carcinoma SKOV3 cell line after 4 hr of compound exposure In vitro cellular toxicity against human ovarian carcinoma SKOV3 cell line after 4 hr of compound exposure	[PMID: 12747786]
SiHa	GI₅₀	0.16 μM Compound: 3, DC-81	Anticancer activity against human SiHa cells by SRB method Anticancer activity against human SiHa cells by SRB method	[PMID: 22104151]
SiHa	GI₅₀	0.17 μM Compound: 1, DC-81	Growth inhibition of human SiHa cells Growth inhibition of human SiHa cells	10.1039/C1MD00072A
SiHa	GI₅₀	0.17 μM Compound: 1, DC-81	Cytotoxicity against human SiHa cells after 48 hrs by SRB assay Cytotoxicity against human SiHa cells after 48 hrs by SRB assay	[PMID: 20444601]
SiHa	GI₅₀	0.17 μM Compound: 1, DC-81	Cytotoxicity against human SiHa cells after 24 hrs by WST-1 assay Cytotoxicity against human SiHa cells after 24 hrs by WST-1 assay	[PMID: 20732817]
SiHa	GI₅₀	0.17 μM Compound: 1, DC-81	Anticancer activity against human SiHa cells by SRB method Anticancer activity against human SiHa cells by SRB method	[PMID: 21676506]
SiHa	GI₅₀	0.17 μM Compound: 2, DC-81	Cytotoxicity against human SiHa cells by sulforhodamine B method Cytotoxicity against human SiHa cells by sulforhodamine B method	[PMID: 21459581]
SiHa	GI₅₀	0.17 μM Compound: 3, DC-81	Growth inhibition of human SiHa cells after 48 hrs by SRB assay Growth inhibition of human SiHa cells after 48 hrs by SRB assay	[PMID: 20031423]
SiHa	GI₅₀	0.17 μM Compound: 3, DC-81	Cytotoxicity against human SiHa cells after 48 hrs by SRB assay Cytotoxicity against human SiHa cells after 48 hrs by SRB assay	[PMID: 20673627]
SiHa	GI₅₀	0.17 μM Compound: 4, DC-81	Anticancer activity against human SiHa cells after 48 hrs by SRB assay Anticancer activity against human SiHa cells after 48 hrs by SRB assay	[PMID: 20557981]
SiHa	GI₅₀	0.17 μM Compound: DC-81	Growth inhibition of human SiHa cells by SRB method Growth inhibition of human SiHa cells by SRB method	[PMID: 18207392]
SiHa	GI₅₀	0.17 μM Compound: DC-81	Cytotoxicity against human SiHa cells after 48 hrs by SRB assay Cytotoxicity against human SiHa cells after 48 hrs by SRB assay	[PMID: 20554354]
UV4	IC₅₀	1500 nM Compound: 31 (DC-81)	In vitro cellular toxicity against chinese hamster UV4 cell line after 4 hr of compound exposure In vitro cellular toxicity against chinese hamster UV4 cell line after 4 hr of compound exposure	[PMID: 12747786]
ZR-75-1	GI₅₀	2.34 μM Compound: 1, DC-81	Growth inhibition of human ZR-75-1 cells Growth inhibition of human ZR-75-1 cells	10.1039/C1MD00072A
ZR-75-1	GI₅₀	2.37 μM Compound: 1, DC-81	Cytotoxicity against human ZR-75-1 cells after 48 hrs by SRB assay Cytotoxicity against human ZR-75-1 cells after 48 hrs by SRB assay	[PMID: 20444601]
ZR-75-1	GI₅₀	2.37 μM Compound: 1, DC-81	Cytotoxicity against human ZR-75-1 cells after 24 hrs by WST-1 assay Cytotoxicity against human ZR-75-1 cells after 24 hrs by WST-1 assay	[PMID: 20732817]
ZR-75-1	GI₅₀	2.37 μM Compound: 1, DC-81	Anticancer activity against human ZR-75-1 cells by SRB method Anticancer activity against human ZR-75-1 cells by SRB method	[PMID: 21676506]
ZR-75-1	GI₅₀	2.37 μM Compound: 2, DC-81	Cytotoxicity against human ZR-75-1 cells by sulforhodamine B method Cytotoxicity against human ZR-75-1 cells by sulforhodamine B method	[PMID: 21459581]
ZR-75-1	GI₅₀	2.37 μM Compound: 3, DC-81	Growth inhibition of human ZR-75-1 cells after 48 hrs by SRB assay Growth inhibition of human ZR-75-1 cells after 48 hrs by SRB assay	[PMID: 20031423]
ZR-75-1	GI₅₀	2.37 μM Compound: 3, DC-81	Cytotoxicity against human ZR-75-1 cells after 48 hrs by SRB assay Cytotoxicity against human ZR-75-1 cells after 48 hrs by SRB assay	[PMID: 20673627]
ZR-75-1	GI₅₀	2.37 μM Compound: 3, DC-81	Anticancer activity against human ZR-75-1 cells by SRB method Anticancer activity against human ZR-75-1 cells by SRB method	[PMID: 22104151]
ZR-75-1	GI₅₀	2.37 μM Compound: 4, DC-81	Anticancer activity against human ZR-75-1 cells after 48 hrs by SRB assay Anticancer activity against human ZR-75-1 cells after 48 hrs by SRB assay	[PMID: 20557981]
ZR-75-1	GI₅₀	2.37 μM Compound: DC-81	Growth inhibition of human Zr-75-1 cells by SRB method Growth inhibition of human Zr-75-1 cells by SRB method	[PMID: 18207392]
ZR-75-1	GI₅₀	2.37 μM Compound: DC-81	Cytotoxicity against human ZR-75-1 cells after 48 hrs by SRB assay Cytotoxicity against human ZR-75-1 cells after 48 hrs by SRB assay	[PMID: 20554354]

体外研究
(In Vitro)

Antibiotic DC 81 对人黑素瘤细胞株 B16、A375、A2058 和 RPMI7951 具有细胞毒性，IC₅₀ 值分别为 4.4 μM、18.5 μM、31.0 μM 和 41.5 μM^[1]^[2]。
Antibiotic DC 81 通过在 N10-C11 处的亲电氨基醇胺功能与 DNA 小槽中的鸟嘌呤 N2 共价结合，显示其生物活性^[1]。
Antibiotic DC 81 (4 μM, 24 h) 诱导线粒体依赖性凋亡^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[2]

Cell Line:	B16 melanoma cells
Concentration:	4 μM
Incubation Time:	24 h
Result:	Induced mitochondria dependent apoptosis.

体内研究
(In Vivo)

Antibiotic DC 81 (0-10 mg/kg，腹腔注射，注射肿瘤细胞后第4、7、10、13天)可降低荷瘤小鼠的肿瘤负担，但 10 mg/kg 剂量的 Antibiotic DC 81 会显著损害心肌酶和肝功能^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female C57BL/6 mice (8-12 weeks old, B16 cells were injected into the tail veins of mice)^[2]
Dosage:	0.1, 1, 10 mg/kg
Administration:	i.p., at day 4, 7, 10, 13 after tumor cell injection
Result:	Substantially decreased the tumor burden by 20% at 1 mg/kg. DC-81 at 10 mg/kg induced an 8-10-fold increase of GPT and a 6-8-fold increase in CPK, which indicated severe impaired liver function and muscle damage. Did not impair significant renal function as demonstrated by serum creatinine.

分子量

246.26

Formula

C₁₃H₁₄N₂O₃

CAS 号

81307-24-6

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

产品使用指南 (1538 KB)

参考文献

[1]. Hu WP, et al. Biological evaluation of an antibiotic DC-81-indole conjugate agent in human melanoma cell lines. Kaohsiung J Med Sci. 2003 Jan;19(1):6-12. [Content Brief]

[2]. Lee CH, et al. Pyrrolo[2,1-c][1,4]benzodiazepine and indole conjugate (IN6CPBD) has better efficacy and superior safety than the mother compound DC-81 in suppressing the growth of established melanoma in vivo. Chem Biol Interact. 2009 Aug 14;180(3):360-7. [Content Brief]

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量		浓度		体积		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Antibiotic DC 81 (Synonyms: DC 81)

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