2. Metabolic Enzyme/Protease
  3. E1/E2/E3 Enzyme
  4. Antitumor agent-153

Antitumor agent-153 (compound 11b) 是基于 PRT4165 (HY-19817) 优化的 H2A 组蛋白泛素化抑制剂。Antitumor agent-153 可抑制人骨肉瘤 U2OS 细胞的活力并减少组蛋白 H2A 单泛素化，具有抗癌活性。

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Antitumor agent-153 Chemical Structure

Antitumor agent-153 Chemical Structure

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Antitumor agent-153 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitumor agent-153 (compound 11b) is an optimized H2A histone ubiquitination inhibitor based on PRT4165 (HY-19817). Antitumor agent-153 inhibits the viability of human osteosarcoma U2OS cells and reduces histone H2A monoubiquitination, exhibiting anticancer activity[1].

体外研究
(In Vitro)

Antitumor agent-153 对 U2O 细胞的抑制效力 IC50 为 5.86 μM，并在 30 μM 条件下完全抑制其增殖[1]。
H2AK119ub1 水平的降低会扰乱肿瘤的发展和癌细胞的生长。而 Antitumor agent-153 (24-96 μM; 1 h) 可以剂量依赖性方式显着降低 U2O 细胞中的 H2AK119ub1 水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-153 相关抗体:

Cell Viability Assay[1]

Cell Line: U2O cells
Concentration: 6 μM, 12 μM, 24 μM, 48 μM, 96 μM
Incubation Time: 1 h
Result: Significantly decreased H2AK119ub1 levels in cells in a dose-dependent manner (24-96 μM).
分子量

324.24

Formula

C16H8N2O6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor agent-153 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-153Antitumor agent153Antitumor agent 153E1/E2/E3 EnzymeE1 activating enzymeE2 conjugating enzymeE3 ligating enzymeUbiquitin activating enzymeUbiquitin conjugating enzymeUbiquitin ligaseInhibitorinhibitorinhibit

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产品名称：
Antitumor agent-153
目录号：
HY-163518
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