2. Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Apoptosis Reactive Oxygen Species (ROS)
  4. Apoptosis inducer 41

Apoptosis inducer 41 是一种通过线粒体途径诱导细胞凋亡 (apoptosis) 的凋亡诱导剂。Apoptosis inducer 41 对 MCF-7 细胞表现出显著的抑制作用 (IC50 = 6.2 μM)。Apoptosis inducer 41 显著阻滞 MCF-7 细胞于 G2/M 期，增加 ROS 的积累，诱导线粒体膜电位去极化。Apoptosis inducer 41 可用于乳腺癌的研究。

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Apoptosis inducer 41

Apoptosis inducer 41 Chemical Structure

CAS No. : 3085940-57-1

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Apoptosis inducer 41 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Apoptosis inducer 41 is an apoptosis inducer that induces apoptosis through the mitochondrial pathway. Apoptosis inducer 41 exhibits remarkable inhibitory effects against MCF-7 cells (IC50 = 6.2 μM). Apoptosis inducer 41 significantly arrests MCF-7 cells in the G2/M phase, increases ROS accumulation, induces mitochondrial membrane potential depolarization. Apoptosis inducer 41 can used for the study of breast cancer[1].

体外研究
(In Vitro)

Apoptosis inducer 41 (Compound 6j) (1‑100 μM, 48 h) 在多种细胞中表现出抗增殖活性，对 MDA-MB-231、MDA-MB-468、MCF-7 和 MCF-10A 细胞的 IC50 分别为 7.1、40.9、6.2 和 46.1[1]。
Apoptosis inducer 41 (1-9 μM, 24-48 h) 通过线粒体凋亡途径显著诱导 MCF-7 细胞凋亡，并将细胞阻滞于 G2/M 期[1]。
Apoptosis inducer 41 (1-9 μM, 24 h) 诱导活性氧 (ROS) 生成并损害线粒体膜电位 (MMP)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis inducer 41 相关抗体:

Apoptosis Analysis[1]

Cell Line: MCF-7 cells
Concentration: 1, 3 and 9 nM
Incubation Time: 48 h
Result: Observed the presence of nuclear collapse and the enhancement of red and bright blue fluorescence.
Increased the early apoptosis rates of MCF-7 cells ranged from 1.92% to 16.87%, while the late apoptosis rates ranged from 0.23% to 19.43%.

Cell Cycle Analysis[1]

Cell Line: MCF-7 cells
Concentration: 1, 3 and 9 nM
Incubation Time: 24 h
Result: Promoted the G2/M phase block in a concentration-dependent manner.

Western Blot Analysis[1]

Cell Line: MCF-7 cells
Concentration: 1, 3 and 9 nM
Incubation Time: 48 h
Result: Significantly upregulated the levels of cytochrome c and cleaved caspase 8.
Increased the ratio of cleaved PARP to PARP.

Immunofluorescence[1]

Cell Line: MCF-7 cells
Concentration: 1, 3 and 9 nM
Incubation Time: 24 h
Result: Increased the ROS levels by 30.67 %, 65.33 %, and 168.00 %, respectively.
Caused the MMP of MCF-7 cells depolarizes with increasing concentrations, which is characterized by a gradual decrease in the red/green fluorescence ratio.
分子量

721.77

Formula

C39H53BrN4O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Apoptosis inducer 41 相关分类

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Keywords:

Apoptosis inducer 413085940-57-1Apoptosis inducer41Apoptosis inducer-41ApoptosisReactive Oxygen Species (ROS)Diosgenin derivatives1,2,3-TriazoleAnti-breast cancerInhibitorinhibitorinhibit

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