2. Apoptosis
  3. Apoptosis Bcl-2 Family Caspase MDM-2/p53
  4. Apoptosis inducer 43

Apoptosis inducer 43 是一种凋亡 (apoptosis) 诱导剂。Apoptosis inducer 43 可以诱导 HCT116 细胞凋亡 (apoptosis)，SubG0-G1 细胞周期停滞、继发性坏死，上调 caspase-3、p53 和 Bax/Bcl-2表达。Apoptosis inducer 43 在实体艾氏癌 (SEC) 小鼠模型中可抑制肿瘤生长。Apoptosis inducer 43 可用于结肠癌、白血病、非小细胞肺癌等癌症的研究。

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Apoptosis inducer 43

Apoptosis inducer 43 Chemical Structure

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Apoptosis inducer 43 相关抗体

Top Publications Citing Use of Products

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Apoptosis inducer 43 is an apoptosis inducer. Apoptosis inducer 43 can induce apoptosis, SubG0-G1 cell cycle arrest, secondary necrosis, and upregulate caspase-3, p53, and Bax/Bcl-2 expression in HCT116 cells. Apoptosis inducer 43 can inhibit tumor growth in a solid Ehrlich carcinoma (SEC) mouse model. Apoptosis inducer 43 can be used to study cancers such as colon cancer, leukemia, and non-small cell lung cancer[1].

IC50 & Target[1]

Caspase 3

 

Bcl-2

 

Bax

 

体外研究
(In Vitro)

Apoptosis inducer 43 (Compound 5f) (10 μM) 表现出抗癌活性，对 NCI 60 细胞 (白血病、非小细胞肺癌、结肠癌、中枢神经系统癌、黑色素瘤、卵巢癌、肾前列腺癌和乳腺癌) 的平均抑制率超过 80%，平均 GI50 低于 5 μM [1]。
Apoptosis inducer 43 (1.79-10 μM，24 小时) 在 HCT-116 细胞中可诱导细胞周期停滞，主要在 SubG0/G1 期，并诱导凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis inducer 43 相关抗体:

Cell Cycle Analysis[1]

Cell Line: HCT-116 cells
Concentration: 10 μM
Incubation Time: 24 h
Result: Induced changes in cell cycle distribution, leading to cell cycle arrest in the SubG0-G1 phase, with the percentage of cells in the G0/G1 cycle increasing from 7% (control sample) to 44%.
Resulted in reduction of the percentage of cells in the remaining phases, G0-G1, S and G2/M.

Apoptosis Analysis[1]

Cell Line: HCT-116 cells
Concentration: 1.79 μM
Incubation Time: 24 h
Result: Decreased the percentage of live cells and increased the proportion of necrotic cells.
Increased the levels of caspase-3, p53, and Bax proteins, and decreased the level of Bcl-2 protein.
体内研究
(In Vivo)

Apoptosis inducer 43 (Compound 5f) (10 mg/kg，腹腔注射，每周三次，共 14 天) 在实体艾氏癌 (SEC) 小鼠模型中显示出抗肿瘤作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SEC (0.2 mL/mouse) female Swiss albino mice (18-22g) model[1]
Dosage: 10 mg/kg
Administration: i.p., three times weekly, 14 days
Result: Demonstrated antitumor effects, resulting in a 72.5% reduction in tumor volume and a 76% reduction in tumor weight.
Showed small foci of tumor cells with distinct mitotic figures were surrounded by large areas of necrosis.
Reduced mitotic cell counts and VEGF expression.
分子量

560.56

Formula

C32H27F3N2O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Apoptosis inducer 43 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apoptosis inducer 43Apoptosis inducer43Apoptosis inducer-43ApoptosisBcl-2 FamilyCaspaseMDM-2/p53apoptosisInhibitorHCT116 cellsSEC mouse modelleukemianon-small cell lung cancerinhibitorinhibit

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