2. GPCR/G Protein Neuronal Signaling
  3. Arrestin Adrenergic Receptor
  4. Arrestin-3 modulator-1

Arrestin-3 modulator-1 (Compound LSH-3) 是一种 Arrestin-3 调节剂。Arrestin-3 modulator-1 在域间界面与 Arrestin-3 结合。Arrestin-3 modulator-1 增强 Arrestin-3 向细胞中磷酸化缺陷型 β2AR 的募集，并提高 FRET 水平。Arrestin-3 modulator-1 可用于视网膜变性、甲状腺功能亢进以及肥胖等先天性疾病研究。

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Arrestin-3 modulator-1

Arrestin-3 modulator-1 Chemical Structure

CAS No. : 1386112-75-9

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Arrestin-3 modulator-1 相关抗体

Top Publications Citing Use of Products

查看 Arrestin 亚型特异性产品:

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Arrestin-2/β-Arrestin 1 Arrestin-3/β-Arrestin 2

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α adrenergic receptor β adrenergic receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Arrestin-3 modulator-1 (Compound LSH-3) is an arrestin-3 modulator. Arrestin-3 modulator-1 binds arrestin-3 at the interdomain interface. Arrestin-3 modulator-1 enhances recruitment of arrestin-3 to phosphorylation-deficient β2AR in cells with increase of FRET levels. Arrestin-3 modulator-1 can be used for congenital disorders like retinal degeneration, hyperthyroidism and obesity research[1].

IC50 & Target[1]

Arrestin-3/β-Arrestin 2

 

Beta-2 adrenergic receptor

 

分子量

454.52

Formula

C24H30N4O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Arrestin-3 modulator-1 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Arrestin-3 modulator-11386112-75-9ArrestinAdrenergic ReceptorBeta ReceptorModulatorArrestin-3β2ARN2a cellsHEK293 cellsCongenital disordersRetinal degenerationHyperthyroidismObesityInhibitorinhibitorinhibit

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