2. PI3K/Akt/mTOR Immunology/Inflammation
  3. PIKfyve Interleukin Related MHC
  4. AS2677131

AS2677131 是一种强效且具有口服活性的 PIKfyve 抑制剂。AS2677131 通过 PIKfyve-c-Rel 通路抑制 IL-12p40、IL-6 和 IL-1β。AS2677131 选择性抑制 c-Rel 与 IL-12p40 和 IL-1β 启动子的 DNA 结合活性。AS2677131 抑制 B 细胞上MHC II 类分子的表达。AS2677131 可用于炎症和免疫学研究，如关节炎。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

AS2677131

AS2677131 Chemical Structure

CAS No. : 2171502-44-4

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

AS2677131 相关抗体

Top Publications Citing Use of Products

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

查看 MHC 亚型特异性产品:

查看所有亚型
MHC I MHC II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AS2677131 is a potent and orally active PIKfyve inhibitor. AS2677131 inhibits f IL-12p40, IL-6 and IL-1β through a PIKfyve-c-Rel pathway. AS2677131 selectively inhibits DNA-binding activity of c-Rel to IL-12p40 and IL-1β promoter. AS2677131 inhibits MHC class II expression on B cells. AS2677131 can be used for the researches of inflammation and immunology, such as arthritis[1].

IC50 & Target[1]

IL-12

 

IL-1β

 

IL-6

 

MHC II

 

体外研究
(In Vitro)

AS2677131 抑制 IL-12p40 的产生，IC50 值为 2.4 nM， 并降低 RAW264.7 小鼠巨噬细胞中 IL-1β 和 IL-6 的水平[1]。
AS2677131 (0.1-10000 nM) 可抑制小鼠腹腔巨噬细胞中的 IL-12p40 和 IL-6[1]。
AS2677131 (0.1-10000 nM) 能抑制小鼠骨髓来源的树突状细胞中的 IL-12p40 和 IL-6[1]。
AS2677131 (10 μM) 对 Ramos 细胞中细胞内 Ca2+ 内流无显著影响[1]。
AS2677131 (200 nM) 可抑制 RAW264.7 细胞中 PI (3,5) P2 的产生，抑制率超过 90%[1]。
AS2677131 (100 nM, 2 h) 会增大 RAW264.7 细胞的体积，并诱导细胞质中产生大量小囊泡[1]。
AS2677131 (10-100 nM, 2h) 会降低 RAW264.7 细胞中启动子的活性，并抑制 c-Rel 与 IL-12p40 和 IL-1β 启动子的结合[1]。
AS2677131 (100 nM, 2 h) 会降低 RAW264.7 细胞中的 p-Akt 水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AS2677131 相关抗体:

Western Blot Analysis[1]

Cell Line: RAW264.7 cells
Concentration: 100 nM
Incubation Time: 2 h
Result: Reduced p-Akt levels.
体内研究
(In Vivo)

AS2677131 (1-30 mg/kg，口服) 可降低经 Poly (I:C) (HY-107202) 和 MDP (HY-127090) 处理的大鼠血浆中 IL-12p40、IL-6 和 TNFα 的水平[1]。
AS2677131 (1-10 mg/kg，口服) 可降低大鼠 CD45R+ B 细胞表面 MHC II 类分子的表达[1]。
AS2677131 (1-10 mg/kg，口服，每日一次，持续 24 天) 可减轻佐剂诱导的关节炎大鼠的炎症[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats with adjuvant-induced arthritis[1]
Dosage: 1, 3 and 10 mg/kg
Administration: Orally administration, daily for 24 days
Result: Reduced paw swelling (swelling inhibition rates of 34.3% and 78.3% at doses of 3 and 10 mg/kg, respectively).
Reversed body weight loss.
Decreased joint histological scores (including bone destruction, cartilage destruction, synovial thickening, and inflammatory cell infiltration.
Reduced the proportion of CD3-CD45RA+CD62Llow activated B cells in peripheral blood.
分子量

470.57

Formula

C27H30N6O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AS2677131 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AS26771312171502-44-4AS 2677131AS-2677131PIKfyveInterleukin RelatedMHCFYVE domain-containing phosphatidylinositol 3-phosphate 5-kinasePhosphatidylinositol 3-phosphate 5-kinaseFab1ILMajor Histocompatibility ComplexIL-12p40IL-6IL-1βc-RelMHC class IIB cellsArthritisInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
AS2677131
目录号：
HY-123876
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z