1. GPCR/G Protein MAPK/ERK Pathway
  2. Ras
  3. ASP6918

ASP6918 是一种有效的口服活性 KRAS G12C 抑制剂,IC50 值为 0.028 µM。ASP6918 抑制细胞生长。ASP6918 显示出抗肿瘤活性。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

ASP6918 Chemical Structure

ASP6918 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

查看 Ras 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ASP6918 is a potent and orally active KRAS G12C inhibitor with an IC50 value of 0.028 µM. ASP6918 inhibits cell growth. ASP6918 shows antitumor activity[1].

IC50 & Target[1]

KRas G12C

0.028 μM (IC50)

体外研究
(In Vitro)

ASP6918 (compound 29a) (6 days) 抑制 NCI-H1373 细胞的细胞生长,IC50 值为 0.0061 µM[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: NCI-H1373 cells
Concentration:
Incubation Time: 6 days
Result: Inhibited cell growth with an IC50 value of 0.0061 µM.
体内研究
(In Vivo)

ASP6918 (10, 20, 40, 60 mg/kg; p.o.; daily for 13 days) 在 NCI-H1373 异种移植小鼠模型中显示出抗肿瘤活性[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Four-week-old male nude mice (NCI-H1373 xenograft mouse model)[1]
Dosage: 10, 20, 40, 60 mg/kg
Administration: Oral, daily for 13 days
Result: Inhibited of tumor growth with tumor growth inhibition (TGI) rate of 27%, 68%, 49%, 73% at 10, 20, 40, 60 mg/kg.
分子量

621.77

Formula

C36H43N7O3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

ASP6918 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
ASP6918
目录号:
HY-162249
需求量: