2. Anti-infection PROTAC
  3. Antibiotic Bacterial Fungal Molecular Glues
  4. Asukamycin

Asukamycin 是一种 manumycin 型代谢产物，可以从 Streptomyces nodosus subsp. asukaensis 中分离出来。Asukamycin 是一种抗生素 (antibiotic)，具有抗菌活性。Asukamycin 抑制多种肿瘤细胞系的生长。

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Asukamycin

Asukamycin Chemical Structure

CAS No. : 61116-33-4

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500 μg ￥7820
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Asukamycin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Asukamycin, a manumycin-type metabolite, could be isolated from Streptomyces nodosus subsp. asukaensis. Asukamycin is an antibiotic and has antimicrobial activity. Asukamycin inhibits growth of various tumor cell lines[1][2].

体外研究
(In Vitro)

Asukamycin (1-50 μM; 24 h) 以浓度依赖的方式降低五种不同人类细胞系的活力，其 IC50 值为 1-5 μM[1]。
Asukamycin (50 μM; 24 and 72 h; THP-1 细胞) 导致细胞内 caspase 8 和 caspase 3 活性显著增加[1]。
Asukamycin (0-100 mcg/mL; 细菌, 18 h; 真菌, 72 h) 具有抗菌活性。Asukamycin 在 0.78-12.5 mcg/mL 的浓度范围内抑制革兰氏阳性菌的生长，在 25 mcg/mL 的浓度范围内抑制 Trichophyton mentagrophytes 的生长。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Asukamycin 相关抗体:

Cell Viability Assay[1]

Cell Line: Human myeloid THP-1, HL-60, U-118 MG, U-87 MG and U-937 cells
Concentration: 1-50 μM
Incubation Time: 24 hours
Result: Reduced viability of five different cell lines in a concentration-dependent manner.
体内研究
(In Vivo)

Asukamycin (0-450 mg/kg; i.p.; 小鼠) 体内毒性低。Asukamycin 具有急性毒性，腹腔注射时 LD50 值为 48.5 mg/kg[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice[2]
Dosage: 0-450 mg/kg
Administration: Intraperitoneal injection
Result: Had no effect on mice when administered by 450 mg/kg and the acute toxicity (LD50) was 48.5 mg/kg by intraperitoneal injection.
分子量

546.61

Formula

C31H34N2O7
CAS 号
性状

固体

颜色

Light yellow to yellow

结构分类
初始来源

Streptomyces nodosus subsp. asukaensis.
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥95.0%

COA (259 KB)

产品使用指南 (1538 KB)
参考文献

Asukamycin 相关分类

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Asukamycin61116-33-4AntibioticBacterialFungalMolecular GluesmanumycinStreptomyces nodosus subsp. asukaensisantimicrobialtumor cell linesInhibitorinhibitorinhibit

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HY-118893
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