2. Immunology/Inflammation
  3. COX
  4. Axinelline A

Axinelline A 是一种有效的 COX 抑制剂，对 COX-2 和 COX-1 的 IC50 分别为 2.22 μΜ 和 8.89 μM。Axinelline A 显示抗炎活性。

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Axinelline A Chemical Structure

Axinelline A Chemical Structure

CAS No. : 1593741-99-1

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Axinelline A 相关抗体

Top Publications Citing Use of Products

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COX COX-1 COX-2 COX-3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Axinelline A is a potent COX inhibitor with IC50s of 2.22 μM and 8.89 μM against COX-2 and COX-1, respectively. Axinelline A shows anti-inflammatory activity[1].

IC50 & Target[1]

COX-2

2.22 μM (IC50)

COX-1

8.89 μM (IC50)

体外研究
(In Vitro)

Axinelline A (2-30 μM; 24 h) 抑制脂多糖 (LPS; HY-D1056) 诱导的 RAW264.7 细胞中促炎因子 (NO、TNF-α、IL-6、IL-1β 和 PGE2) 的表达[1]。
Axinelline A (2-30 μM; 24 h) 抑制 LPS 诱导的 RAW264.7 细胞 NF-κB 信号通路[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Axinelline A 相关抗体:

Western Blot Analysis[1]

Cell Line: RAW264.7 cells
Concentration: 2, 10 and 30 μM
Incubation Time: 24 h
Result: Diminished LPS-induced expression of nitric oxide synthase (iNOS) and COX-2 protein levels. The phosphorylation level of NF-κB increased after 30 min of LPS treatment, but pretreatment with test compound reduced the level of phosphorylation in a dose-dependent manner. The phosphorylation of IKK and IκBα was inhibited in a dose-dependent manner.
分子量

269.25

Formula

C12H15NO6
CAS 号
结构分类
初始来源

Streptomyces axinellae
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Axinelline A 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Axinelline A1593741-99-1COXCyclooxygenaseiNOSNOTNF-αIL-6IL-1βRAW264.7Inhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-N11624
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