2. GPCR/G Protein
  3. Protease Activated Receptor (PAR)
  4. AY77

AY77 是一种钙偏向的 PAR2 激动剂。AY77 在 PAR2 介导的 Gq 通路激活和 β-arrestin-2 募集中的 EC50 分别为 0.17 和 2 nM。AY77 有效诱导细胞内 Ca2+ 释放。

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Custom Peptide Synthesis

AY77 Chemical Structure

AY77 Chemical Structure

CAS No. : 1835734-92-3

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规格 价格 是否有货 数量
1 mg ￥5544
1 周
5 mg   询价  
10 mg   询价  

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AY77 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AY77 is a calcium-biased PAR2 agonist. AY77 shows an EC50 of 0.17 and 2 nM in PAR2-mediated the activation in the Gq pathway and recruitment of β-arrestin-2, respectively. AY77 potently induces intracellular Ca2+ release[1][2].

IC50 & Target

PAR2[1]
分子量

404.50

Formula

C21H32N4O4
CAS 号
Sequence

{5-Isoxazolylcarbonyl-Cha}-{Chg}-NH2
Sequence Shortening

{5-Isoxazolylcarbonyl-Cha}-{Chg}-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

AY77 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AY771835734-92-3AY 77AY-77Protease Activated Receptor (PAR)Thrombin receptorsbiasedβ-arrestin-2Gqbreast cancerprostate cancerInhibitorinhibitorinhibit

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目录号：
HY-138951
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