2. Apoptosis
  3. Bcl-2 Family
  4. Bcl-2-IN-2

Bcl-2-IN-2 是一种有效的选择性 Bcl-2 抑制剂，IC50 为 0.034 nM，也可抑制 Bcl-xL，IC50 为 43 nM，对 Bcl-2 的活性是 Bcl-xL 的 1000多倍。

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Bcl-2-IN-2 Chemical Structure

Bcl-2-IN-2 Chemical Structure

CAS No. : 2383085-86-5

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Bcl-2-IN-2 相关抗体

Top Publications Citing Use of Products

查看 Bcl-2 Family 亚型特异性产品:

查看所有亚型
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bcl-2-IN-2 is a potent and selective Bcl-2 inhibitor with an IC50 of 0.034 nM and also inhibits Bcl-xL with an IC50 of 43 nM, showing >1000-fold selectivity for Bcl-2 over Bcl-xL[1].

IC50 & Target[1]

Bcl-2

0.034 nM (IC50)

Bcl-xL

43 nM (IC50)

体外研究
(In Vitro)

Bcl-2-IN-2 inhibits mutant Bcl-2-G101V with an IC50 of 1.2 nM. Bcl-2-IN-2 inhibits RS4;11 cellular proliferation with an IC50 of 1.9 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Bcl-2-IN-2 相关抗体:
分子量

876.07

Formula

C48H57N7O7S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Bcl-2-IN-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bcl-2-IN-22383085-86-5Bcl-2 FamilyInhibitorinhibitorinhibit

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