1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. β3-AR agonist 1

β3-AR agonist 1 

目录号: HY-101514
产品使用指南

β3-AR agonist 1 (compound 15) 是一种高效选择性的,可口服的 β3-肾上腺素能受体 (β3-AR) 激动剂 (EC50=18 nM),对 β1-、β2-、α1A-AR 无活性 (β1/β3, β2/β3, α1A/β3>556倍)。

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β3-AR agonist 1 Chemical Structure

β3-AR agonist 1 Chemical Structure

CAS No. : 1283125-73-4

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  • 生物活性

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生物活性

β3-AR agonist 1 (compound 15) is a highly potent, selective, and orally available β3-adrenergic receptor (β3-AR) agonist (EC50=18 nM), being inactive to β1-, β2-, and α1A-AR (β1/β3, β2/β3, and α1A/β3>556-fold)[1].

IC50 & Target

EC50: 18 nM (β3-AR)[1]

体内研究
(In Vivo)

β3-AR agonist 1 (compound 15) shows dose-dependent β3-AR-mediated responses in marmoset urinary bladder smooth muscle, has a desirable metabolic stability and pharmacokinetic profile (Cmax and AUC), and do not obviously affect heart rate or mean blood pressure when administered intravenously (3 mg/kg) to anesthetized rats[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

444.55

Formula

C22H28N4O4S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
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  • 稀释计算器

The molarity calculator equation

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质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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β3-AR agonist 1
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HY-101514
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