β-Casomorphin, bovine TFA  (Synonyms: β-Casomorphin-7 (bovine) (TFA); Bovine β-casomorphin-7 TFA)

β-Casomorphin, bovine TFA (β-Casomorphin-7 (bovine) TFA) is a opioid peptide with an IC₅₀ of 14 μM in an Opioid receptors binding assay^[1].

IC50: 14 μM (Opioid receptor)^[1]

β-Casomorphin, bovine TFA (0.1μM; 30 minutes-24 hours) stimulates the secretion of mucin in DHE Cells after 8 h of treatment^[2].
β-Casomorphin, bovine TFA (0.1μM; 24 hours) induces an increase in rMuc2 and rMuc3 mRNA levels^[2].
β-Casomorphin, bovine TFA does not modify the expression of rMuc1, rMuc4, and rMuc5AC^[2].
β-Casomorphin, bovine TFA (0.1μM; 24 hours) stimulates MUC5AC expression and mucin Secretion in HT29-MTX Cells (human)^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

β-Casomorphin, bovine TFA (7.5×10⁻⁶ mol/day/kg ; i.g.; for 30 days) increases plasma insulin and decreased plasma glucagon of diabetic rats^[3].
β-Casomorphin, bovine TFA (7.5×10⁻⁶ mol/day/kg ; i.g.; for 30 days) alters the changes of SOD, GPx, T-AOC, MDA and H2O2 in the kidney of diabetic rats^[3].
β-Casomorphin, bovine TFA (7.5×10⁻⁶ mol/day/kg ; i.g.; for 30 days) reduces MDA (significantly) and H2O2 (non-significantly) level in the kidney compared to the diabetic rats^[3].
β-Casomorphin, bovine TFA (7.5×10⁻⁶ mol/day/kg ; i.g.; for 30 days) alleviates high glucose-induced decreasement in SOD and GPx activity, increasement in MDA contents in the NRK-52E cells^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

903.94

C₄₃H₅₆F₃N₇O₁₁

Tyr-Pro-Phe-Pro-Gly-Pro-Ile

YPFPGPI

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Brantl V, et al. Opioid activities of beta-casomorphins. Life Sci. 1981 Apr 27;28(17):1903-9.  [Content Brief]

  [2]. Zoghbi S, et al. β-casomorphin-7-7 regulates the secretion and expression of gastrointestinal mucins through a μ-opioid pathway. Am J Physiol Gastrointest Liver Physiol. 2006 Jun;290(6):G1105-13.  [Content Brief]

  [3]. Zhang W, et al. The protective effects of beta-casomorphin-7 against glucose -induced renal oxidative stress in vivo and vitro. PLoS One. 2013 May 3;8(5):e63472.  [Content Brief]