2. Others
  3. Isotope-Labeled Compounds
  4. Betamethasone acetate-d5

Betamethasone acetate-d5 是 Betamethasone acetate (HY-13570B) 氘代物。Betamethasone acetate 是一种糖皮质激素，用于产前预防早产儿的呼吸窘迫综合征 (RDS)。Betamethasone acetate 在孕鼠产前给药时，对后代的体格和大脑发育表现出剂量依赖性效应。Betamethasone acetate 可用于产前干预研究。

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Betamethasone acetate-d<sub>5</sub>

Betamethasone acetate-d5 Chemical Structure

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Other Forms of Betamethasone acetate-d5:

Betamethasone acetate-d5 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Betamethasone acetate-d5 is deuterium labeled Betamethasone acetate (HY-13570B). Betamethasone acetate is a glucocorticoid with prenatal application for preventing respiratory distress syndrome (RDS) in premature infants. Betamethasone acetate exhibits dose-dependent effects on somatic and brain development in offspring when administered prenatally to pregnant rats. Betamethasone acetate can be used for the study of antenatal intervention[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Betamethasone acetate-d5 相关抗体:
体内研究
(In Vivo)

Betamethasone acetate (0.125-0.25 mg/kg，肌内注射，单剂量) 改善早产羊的胎肺成熟[1]。
Betamethasone (170-340 μg/kg，鼻内给药，在胚胎第 20 天 4 小时内给药两次) (acetate) 在孕期 Fisher 344 大鼠的后代中诱导适度的剂量依赖性体格生长迟缓 (出生体重、冠尾长度、头部直径减少)[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Preterm sheep (122 days of gestation)[1]
Dosage: 0.125, 0.25 mg/kg
Administration: i.m., single dose
Result: Improved fetal lung maturation in preterm sheep.
Increased the mRNA expression of surfactant proteins A, B, C (SFTPA, SFTPB, SFTPC), ABCA3, and AQP5 in fetal sheep lungs.
Animal Model: 3-month-old time-pregnant Fisher 344 dams[2]
Dosage: 170, 340 μg/ kg
Administration: i.n., twice within 4 h on E20
Result: Induced moderate dose-dependent somatic growth retardation.
Caused significant brain growth retardation in offspring.
Exhibited chronically anti-proliferative effects on brain cells.
分子量

439.53

Formula

C24H26D5FO6
非标记 CAS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Betamethasone acetate-d5 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Betamethasone acetate-d5Isotope-Labeled CompoundsInhibitorinhibitorinhibit

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产品名称：
Betamethasone acetate-d5
目录号：
HY-13570BS1
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