1. Antibody-drug Conjugate/ADC Related PROTAC
  2. ADC Linker PROTAC Linkers
  3. Bis-PEG17-NHS ester

Bis-PEG17-NHS ester 是一种 PROTAC 连接桥,属于 PEG 类和 Alkyl/ether 类。Bis-PEG17-NHS ester 可用于合成一系列 PROTAC 分子。Bis-PEG17-NHS ester 是一种可降解 (cleavable) 的 ADC 连接桥,用于抗体活性分子结合物 (ADCs) 的合成。

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Bis-PEG17-NHS ester Chemical Structure

Bis-PEG17-NHS ester Chemical Structure

CAS No. : 2221948-93-0

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bis-PEG17-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG17-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target[1]

PEGs

 

Alkyl/ether

 

Cleavable Linker

 

体外研究
(In Vitro)

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1061.13

Formula

C46H80N2O25

CAS 号
性状

固液混合物

颜色

Colorless to off-white

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献
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  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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产品名称:
Bis-PEG17-NHS ester
目录号:
HY-130826
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