2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. Boc-PEG2-Val-Cit-PAB-OH

Boc-PEG2-Val-Cit-PAB-OH 是一种酶切 ADC 连接子，具有 Boc 保护的胺、亲水性 PEG 间隔物和 Val-Cit-PAB 二肽。PAB 上的苄醇可用于连接反应基团（例如 PNP），以与药物有效载荷结合。可以用酸去除 Boc 保护基以露出一级胺，该一级胺可用于偶联反应以形成酰胺。Val-Cit-PAB 被细胞蛋白酶裂解，以有效地将有效载荷释放到细胞中。

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Boc-PEG2-Val-Cit-PAB-OH Chemical Structure

Boc-PEG2-Val-Cit-PAB-OH Chemical Structure

CAS No. : 2055024-55-8

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Boc-PEG2-Val-Cit-PAB-OH 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

生物活性

Boc-PEG2-Val-Cit-PAB-OH is an enzyme-cleavable ADC linker featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit-PAB dipeptide. The benzylic alcohol on the PAB can be used to attach with reactive groups such as PNP for conjugation with drug payloads. The Boc protecting group may be removed with acid to reveal a primary amine which may be used in coupling reactions to form amides. The Val-Cit-PAB is cleaved by cellular proteases for efficient release of payloads to the cell.

分子量

638.75

Formula

C30H50N6O9
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

Boc-PEG2-Val-Cit-PAB-OH 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

Boc-PEG2-Val-Cit-PAB-OH2055024-55-8ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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