1. GPCR/G Protein Neuronal Signaling
  2. Adrenergic Receptor
  3. BODIPY FL prazosin

BODIPY FL prazosin 是一种荧光 α1-肾上腺素α1-adrenergic 拮抗剂,对 α1a-AR 和 α1b-AR 的 Ki 值分别为 14.5、43.3 nM. BODIPY FL prazosin 也是一种荧光配体,激发和发射波长分别为 485 和 535 nm。BODIPY FL prazosin 可用于研究 α1 -肾上腺素受体亚型的亚细胞定位差异 。

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BODIPY FL prazosin Chemical Structure

BODIPY FL prazosin Chemical Structure

CAS No. : 175799-93-6

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生物活性

BODIPY FL prazosin is a fluorescent α1-adrenergic antagonist with Ki values of 14.5, 43.3 nM for α1a-AR and α1b-AR, respectively. BODIPY FL prazosin also is a fluorescent ligand with the excitation and emission wavelengths are 485 and 535 nm, respectively. BODIPY FL prazosin can be used for study the differences in the subcellular localization of α1-adrenoceptor subtypes[1][2][3].

IC50 & Target[1]

α1A-adrenergic receptor

14.5 nM (Ki)

α1B-adrenergic receptor

43.3 nM (Ki)

体外研究
(In Vitro)

BODIPY FL prazosin (10 nM; 30 min at room temperature in 100 μl; COS-7 cells) shows Affinity of various α1-AR ligands with Ki values of 14.5, 43.3 nM for α1a-AR and α1b-AR, respectively[1].
BODIPY FL prazosin (100 nM, 30 min) can be used as molecular probe for the Visualization of the non-adrenoceptor binding site of α1-adrenergic drugs in erythroleukemia cells[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

563.41

Formula

C28H32BF2N7O3

CAS 号
Emission (Em)

510

Excitation (Ex)

502

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

BODIPY FL prazosin 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
BODIPY FL prazosin
目录号:
HY-D1606
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