2. GPCR/G Protein
  3. Angiotensin Receptor
  4. Brain Natriuretic Peptide (1-32), rat acetate

Brain Natriuretic Peptide (1-32), rat acetate  (Synonyms: BNP (1-32), rat acetate)

目录号: HY-P1519B 纯度: 99.02%
COA 产品使用指南

摩尔计算器

Brain Natriuretic Peptide (1-32), rat acetate (BNP (1-32), rat acetate) 是一种含有 32 个氨基酸的多肽。可作为心力衰竭病人病残率和死亡率的生化标志。

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Custom Peptide Synthesis

Brain Natriuretic Peptide (1-32), rat acetate Chemical Structure

Brain Natriuretic Peptide (1-32), rat acetate Chemical Structure

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规格 价格 是否有货 数量
1 mg ￥4000
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5 mg ￥10000
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Other Forms of Brain Natriuretic Peptide (1-32), rat acetate:

Brain Natriuretic Peptide (1-32), rat acetate 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Brain Natriuretic Peptide (1-32), rat acetate (BNP (1-32), rat acetate) is a 32 amino acid polypeptide secreted by the ventricles of the heart in response to excessive stretching of heart muscle cells (cardiomyocytes)[1].

体外研究
(In Vitro)

B 型利钠肽 (BNP) 通过降低血压和心室纤维化来对抗心脏压力。大鼠 BNP BNP (1-32) (rBNP (1-32)) 是 BNP 的 45 个残基天然大鼠形式的氨基截短形式[1]。心房利钠肽-(1-28) (ANP)、脑利钠肽-(1-32) (BNP) 和C型利钠肽 (CNP) 均存在于脑内，集中于第三脑室的前腹区并参与体液稳态的调节。ANP (1-28)、BNP (1-32) 和 CNP (1-32) 在哺乳动物大脑中通过其受体 NPR-A 和 NPR-B 调节盐和水稳态[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Brain Natriuretic Peptide (1-32), rat acetate 相关抗体:
体内研究
(In Vivo)

在有意识的自发性高血压大鼠 (SHR) 和用载体或选择性中性内肽酶抑制剂 SQ 28603 处理的有意识的食蟹猴中，比较几种脑钠肽 (BNP) 和心房钠肽 (ANP) 对降压、利钠和环 GMP 的反应。在有意识的 SHR 中，大鼠中 BNP (1-32) 3 nmol/kg i.v. 引起的利尿钠和循环 GMP 反应大于大鼠中 ANP 99-126 和猪 BNP-26，并且通过 100 μmol/kg i.v. SQ 28,603 显着增强。人 BNP-32 在用载体或 SQ 28，603 处理的 SHR 中没有活性。相比之下，1 nmol/kg i.v. 人 BNP (1-32) 刺激有意识的猴子的肾脏引起的抑郁反应大于或等于人 ANP 99-126 引起的反应，而 3 nmol/kg iv 大鼠 BNP (1-32) 降低平均动脉压而不影响肾功能[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

3512.99

Formula

C148H243N47O46S3
性状

固体

颜色

White to off-white

Sequence

Asn-Ser-Lys-Met-Ala-His-Ser-Ser-Ser-Cys-Phe-Gly-Gln-Lys-Ile-Asp-Arg-Ile-Gly-Ala-Val-Ser-Arg-Leu-Gly-Cys-Asp-Gly-Leu-Arg-Leu-Phe (Disulfide bridge: Cys10-Cys26)
Sequence Shortening

NSKMAHSSSCFGQKIDRIGAVSRLGCDGLRLF (Disulfide bridge: Cys10-Cys26)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
纯度 & 产品资料
参考文献

Brain Natriuretic Peptide (1-32), rat acetate 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Brain Natriuretic Peptide (1-32), ratBNP (1-32), ratAngiotensin ReceptorInhibitorinhibitorinhibit

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目录号：
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