2. Apoptosis Immunology/Inflammation Epigenetics
  3. TNF Receptor Interleukin Related Epigenetic Reader Domain
  4. BRD4 Inhibitor-38

BRD4 Inhibitor-38 (Compound 25) 是一种具有口服活性的 BRD4 抑制剂, 其对 BRD4 BD1 和 BRD4 BD2 的 IC50 值分别为 3.64 μM 和 0.12 μM。BRD4 Inhibitor-38 具有抗炎活性，其对一氧化氮 (NO) 生成的 IC50 值为 1.98 μM。

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BRD4 Inhibitor-38

BRD4 Inhibitor-38 Chemical Structure

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BRD4 Inhibitor-38 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BRD4 Inhibitor-38 (Compound 25) is an orally active inhibitor of BRD4 with IC50 values of 3.64 μM and 0.12 μM against BRD4 BD1 and BRD4 BD2, respectively. BRD4 Inhibitor-38 also exhibits anti-inflammatory activity, with an IC50 value of 1.98 μM for inhibiting nitric oxide (NO) production[1].

IC50 & Target[1]

BRD4 BD1

3.64 μM (IC50)

BRD4 BD2

0.12 μM (IC50)

体外研究
(In Vitro)

BRD4 Inhibitor-38 (Compound 25) (2.5-20 μM; 2 h) 在 Raw 264.7 和 THP-1 细胞中具有抗炎活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

BRD4 Inhibitor-38 相关抗体:

Real Time qPCR[1]

Cell Line: Raw 264.7, THP-1
Concentration: 2.5, 5, 10, 20 μM
Incubation Time: 2 h (stimulated with LPS (1 μg/mL) and LPS (100 ng/mL) + IFN-γ (20 ng/mL) for 6 h. note: Compound 25 were pre-treated for 2 h before stimulating with LPS for 6 h.)
Result: Inhibited the mRNA expression of LPS-induced IL-6 and TNF-α in a dependent manner.
体内研究
(In Vivo)

BRD4 Inhibitor-38 (Compound 25) (25-100 mg/kg; p.o.; 单剂量) 在 LPS (10mg/kg; Single dose) (HY-D1056) 诱导的急性炎症小鼠模型中具有抗炎活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LPS-induced mouse model of acute inflammation[1].
Dosage: 25, 50, 100 mg/kg
Administration: Oral administration (p.o.)，single dose. After LPS treatment (10mg/kg; Single dose)
Result: Significantly inhibited the increase of inflammatory genes IL-6 and TNF-α at doses of 50 and 100 mg/kg.
Alleviated lung tissue edema, damage, and lung hemorrhage.
Mitigated kidney damage, significantly increased the proportion of normal renal tubules, improved the internal brush border structure, reduced renal interstitial inflammatory cell infiltration, and decreased the number of interstitial vacuoles at a dose of 100 mg/kg.
分子量

338.36

Formula

C19H18N2O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

BRD4 Inhibitor-38 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRD4 Inhibitor-38TNF ReceptorInterleukin RelatedEpigenetic Reader DomainTumor Necrosis Factor ReceptorTNFRILRaw 264.7THP-1Anti-inflammatory activityInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-170686
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