1. Immunology/Inflammation
  2. STING
  3. BSP16

BSP16 是一种有效的干扰素基因激动剂 (STING) 激动剂,具有口服活性。 BSP16 可以选择性地刺激 STING 通路。BSP16 可用于癌症研究。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

BSP16 Chemical Structure

BSP16 Chemical Structure

CAS No. : 2727249-47-8

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BSP16 is a potent, orally active stimulator of interferon genes (STING) agonist. BSP16 can selectively stimulate the STING pathway. BSP16 can be used for the research of cancer[1].

IC50 & Target

IC50 for STING: 9.24 μM (ISG-THP1 cells); 5.71 μM (ISGRAW264.7 cells)[1]

体外研究
(In Vitro)

BSP16 (0.1-100 μM) can selectively stimulate the STING pathway in ISG-THP1 and ISGRAW264.7 cells with EC50 values of 9.24 and 5.71 μM, respectively[1].
BSP16 (10, 25, 50 μM; 1, 3, 6 h) strongly activates STING signaling in human and mouse cells and binds STING as a homodimer[1].
BSP16 exhibits a promising absorption, distribution, metabolism, excretion and toxicity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[1]

Cell Line: ISG-THP1 cells
Concentration: 10, 25, 50 μM
Incubation Time: 1, 3, 6 h
Result: Robustly induced mRNA expression of target genes IFNβ, CXCL10, and IL6 in response to STING activation, in a time and concentration-dependent manner in ISGTHP1 cells.

Western Blot Analysis[1]

Cell Line: ISG-THP1 cells
Concentration: 10, 25, 50 μM
Incubation Time: 1, 3, 6 h
Result: Rapidly increased the phosphorylation of TBK1 and IRF3 in a concentration-dependent manner.
体内研究
(In Vivo)

BSP16 (po, 50 mg/kg; iv, 5 mg/kg) has well lerated and excellent pharmacokinetic profile[1].
BSP16 (oral, 15 and 30 mg/kg, q3d; oral, 20 mg/kg, q5d) induces tumor regression and durable antitumor immunity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MC38 (colon carcinoma) syngeneic tumor model[1]
Dosage: 15, 30 mg/kg
Administration: oral, q3d
Result: Exhibited tolerated and excellent antitumor efficacy, experienced complete tumor regression (CR) after day 21.
Resulted in robust induction of IFNB and IL6 (30 mg/kg).
Animal Model: CT26 (colon carcinoma) tumor model[1]
Dosage: 20 mg/kg
Administration: oral, q5d
Result: Exhibited tolerated and induced tumor regression in all treated mice within 30 days.
Led to a substantial elevation of IFNB in the plasma in CT26 bearing mice.
Animal Model: Rats[1]
Dosage: 5 mg/kg, 50 mg/kg
Administration: oral and i.v
Result:
compd. adm. Cmax(μg/mL) AUG0-∞(h*μg/mL) t1/2(h) Vss(L/kg) CL(L/h/kg) F(%)
BSP16 po(50 mg/kg) 58.2 315.9 1.60 0.38 0.16 107
iv(5 mg/kg) 29.4 1.04 0.26 0.17
分子量

369.27

Formula

C16H18O5Se

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
BSP16
目录号:
HY-151264
需求量: