Ca(Ⅱ)-EDTA disodium dihydrate  (Synonyms: Calcium disodium EDTA dihydrate)

CaⅡ-EDTA disodium dihydrate (Calcium disodium EDTA dihydrate) is an orally active metal chelating reagent, exhibits bactericidal activities against periodontal pathogens Aggregatibacter actinomycetemcomitans, Prevotella intermedia and Porphyromonas gingivalis^[1]. CaⅡ-EDTA disodium dihydrate is effective chelating antidotes for lead- and cadmium poisoning^[2][3].

CaⅡ-EDTA disodium dehydrate (0-100 mM) 抑制牙周病细菌 A. actinomycetemcomitans，P. intermedia 和 P. gingivalis 的生长，MICs 分别为 70，70 和 60 mM^[1]。
CaⅡ-EDTA disodium dehydrate (0-1000 mM) 对 L929 细胞具有细胞毒性，安全剂量为 75 mM^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CaⅡ-EDTA disodium dehydrate (50 mg/kg，口服 4 周) 以纳米颗粒形式减轻镉对肾脏和骨骼的毒性作用^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

410.30

C₁₀H₁₂CaN₂O₈.2H₂.2Na

6766-87-6

乙二胺四乙酸二钠钙二水合物； Ca(Ⅱ)-EDTA试剂

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Miura, T. et al., Ca (II)-EDTA shows antimicrobial activity against periodontopathic bacteria. Journal of Biomedical Science and Engineering, 5, 10-14.

  [2]. Saleh SM, et al., Do Nanoparticles of Calcium Disodium EDTA Minimize the Toxic Effects of Cadmium in Female Rats? Biol Trace Elem Res. 2023 Sep 18.  [Content Brief]

  [3]. Saxena G, et al., Lead-induced oxidative stress and hematological alterations and their response to combined administration of calcium disodium EDTA with a thiol chelator in rats. J Biochem Mol Toxicol. 2004;18(4):221-33.  [Content Brief]