2. Metabolic Enzyme/Protease
  3. Carbonic Anhydrase
  4. Carbonic anhydrase inhibitor 12

Carbonic anhydrase inhibitor 12 

目录号: HY-115999
产品使用指南

摩尔计算器

碳酸酐酶抑制剂12是一种有效的 CA II 抑制剂，对 CA I 也有抑制活性(CA II与CA I的 Kis分别为1.72 nM和271 nM)。碳酸酐酶抑制剂12对不同的肿瘤细胞系具有较强的抗癌活性。

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Carbonic anhydrase inhibitor 12 Chemical Structure

Carbonic anhydrase inhibitor 12 Chemical Structure

CAS No. : 2883451-38-3

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Carbonic anhydrase inhibitor 12 相关抗体

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查看 Carbonic Anhydrase 亚型特异性产品:

查看所有亚型
CA CA I CA Ⅱ CA Ⅸ CA XII

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Carbonic anhydrase inhibitor 12 is a potent CA II inhibitor, also has inhibitory activity in CA I (Kis of 1.72 and 271 nM in CA II and CA I, respectively). Carbonic anhydrase inhibitor 12 has potent anticancer activity against different cancer cell lines[1].

IC50 & Target

CA Ⅱ

 

体外研究
(In Vitro)

Carbonic anhydrase inhibitor 12 (Compound 14h) (10 μM; 48 hours; single) has great influence on the specificity and the inhibitory potency against the different cancer cell lines[1].
Carbonic anhydrase inhibitor 12 (2.4 μM in MCF-7 and 2.5 μM MDA-MB-231; 48 hours) can arrest the cell cycle of MCF-7 and MDA-MB-231 cells at the G2/M phase[1].
Carbonic anhydrase inhibitor 12 (2.4 μM in MCF-7 and 2.5 μM MDA-MB-231; 48 hours) demonstrates an increase in the early apoptotic and late apoptotic phase in comparison to the control untreated cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Carbonic anhydrase inhibitor 12 相关抗体:

Cell Proliferation Assay

Cell Line: MCF-7, T47D, MDA-MB-231, COLO 205, HCT-116, HT29, SW-620, A549, SK-OV-3 and NCI-ADR-RES[1]
Concentration: 10 μM
Incubation Time: 48 hours
Result: Showed a mean growth inhibitory activity of 55.12% and a broad range of antiproliferative activity against most of the tested cancer cell lines.

Cell Cycle Analysis

Cell Line: MCF-7 and MDA-MB-231[1]
Concentration: 2.4 μM in MCF-7, 2.5 μM MDA-MB-231
Incubation Time: 48 hours
Result: Arrested the cell cycle of MCF-7 and MDA-MB-231 cells at the G2/M phase.

Apoptosis Analysis

Cell Line: MCF-7 and MDA-MB-231[1]
Concentration: 2.4 μM in MCF-7, 2.5 μM MDA-MB-231
Incubation Time: 48 hours
Result: Demonstrated an increase in the early apoptotic and late apoptotic phase in comparison to the control untreated cells.
分子量

640.53

Formula

C27H22BrN5O5S2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Carbonic anhydrase inhibitor 12 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

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