2. NF-κB Immunology/Inflammation Metabolic Enzyme/Protease
  3. Keap1-Nrf2 Interleukin Related Heme Oxygenase (HO)
  4. CD-10

CD-10 是一种具有口服活性且具有血脑屏障通透性的 Keap1-Nrf2 蛋白-蛋白相互作用 (PPI) 抑制剂。CD-10 与 Keap1 结合的 KD 值为 193 nM。CD-10 通过激活 Keap1-Nrf2 通路发挥显著的抗氧化和抗炎作用，具体表现为降低 MDA、IL-4、IL-10 水平，并上调 HO-1 蛋白表达。CD-10 在慢性不可预测温和应激 (CUMS) 小鼠模型中，有效缓解了焦虑和抑郁行为，并通过促进 Nrf2 核转位恢复了血清神经递质水平。CD-10 可用于抑郁症研究。

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CD-10 Chemical Structure

CD-10 Chemical Structure

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CD-10 相关抗体

Top Publications Citing Use of Products

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

查看 Heme Oxygenase (HO) 亚型特异性产品:

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HO-1 HO-2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CD-10 is an orally active and BBB-penatrable Keap1-Nrf2 protein-protein interaction (PPI) inhibitor. CD-10 binds to Keap1 with a KD value of 193 nM. CD-10 exhibits potent anti-oxidative and anti-inflammatory effects through Keap1-Nrf2 pathway activation, evidenced by reduced levels of MDA, IL-4, IL-10 and increased expression of HO-1. CD-10 effectively alleviated anxiety and depressive behaviors and restored serum neurotransmitter levels by promoting Nrf2 nuclear translocation in the chronic unpredictable mild stress (CUMS) mouse model. CD-10 can be used for the study of depression[1].

体外研究
(In Vitro)

CD-10 (10 μM, 24 h) 在 LPS 刺激的 BV2 细胞中显著恢复 GSH 水平，并降低 IL-1β 的浓度[1]。

CD-10 (10 μM, 24 h) 通过降低LPS 刺激的 BV2 细胞模型中 MDA、IL-4和 IL-10 的水平，并增加 HO-1 的水平，激活 Keap1-Nrf2 途径[1]。

CD-10 (10 μM) 诱导 LPS 刺激的 BV2 细胞模型中 Nrf2 的核转位并激活 Nrf2 靶向基因[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CD-10 相关抗体:

Western Blot Analysis[1]

Cell Line: LPS (100 ng/ml)-stimulated BV2 cells
Concentration: 10 μM
Incubation Time: 24 h
Result: Increased the expression level of HO-1.
Didn’t change the protein level of Nrf2 in the cytoplasm and elevated the ratio of the nuclear Nrf2 level to the cytoplasmic Nrf2 level.
体内研究
(In Vivo)

CD-10 (20 mg/kg, i.g., 2 weeks) 可改善慢性不可预测轻度应激 (CUMS) 小鼠模型中的抑郁行为[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8-week male C57BL/6J CUMS mouse model [1]
Dosage: 20 mg/kg
Administration: i.g. 2 weeks
Result: Increased the total movement distance, activity time in the central area, the total entries, percentage of time spent in opened arms and opened arm entries.
Decreased percentage of duration of total immobility in TST and immobility time in FST.
Restored the pleasure derived from sweet foods and the appetite.
Elevated the levels of SOD and GSH, reduced the level of MDA.
Reduced the levels of IL-1β and TNF-α, as well as the increased level of IL-4.
Increased the expression levels of total Nrf2, HO-1and decreased iNOS levels in the hippocampus and cortex.
Increased the nucleus protein levels of Nrf2 and the ratio of nuclear to cytoplasm Nrf2 level.
Increased the binding of Nrf2 to the ARE response element.
分子量

792.92

Formula

C38H44N6O9S2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CD-10 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CD-10CD10CD 10Keap1-Nrf2Interleukin RelatedHeme Oxygenase (HO)ILHeme OxygenaseKeap1Nrf2Anti-depressantlpsCUMSdepressionmajor depressive disorderInhibitorinhibitorinhibit

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