2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. Ceratotoxin-2

Ceratotoxin-2  (Synonyms: CcoTx2; β-TRTX-cm1b)

目录号: HY-P5810
产品使用指南

摩尔计算器

Ceratotoxin-2 (CcoTx2) 是一种电压门控制的钠通道 (sodium channel) 阻滞剂，对 Nav1.2/β1 和 Nav1.3/β1 的 IC50 分别为 8 nM 和 88 nM。

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Custom Peptide Synthesis

Ceratotoxin-2 Chemical Structure

Ceratotoxin-2 Chemical Structure

CAS No. : 880885-98-3

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Ceratotoxin-2 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Ceratotoxin-2 (CcoTx2) is a voltage-gated sodium channel blocker with IC50s of 8 nM and 88 nM against Nav1.2/β1 and Nav1.3/β1, respectively[1].

IC50 & Target

IC50: 8 nM (Nav1.2/β1), 88 nM (Nav1.3/β1), 400 nM (Nav1.4/β1), 407 nM (Nav1.1/β1), 1634 nM (Nav1.5/β1)[1]
分子量

4092.67

Formula

C177H260N52O49S6
CAS 号
Sequence

Asp-Cys-Leu-Gly-Trp-Phe-Lys-Ser-Cys-Asp-Pro-Lys-Asn-Asp-Lys-Cys-Cys-Lys-Asn-Tyr-Thr-Cys-Ser-Arg-Arg-Asp-Arg-Trp-Cys-Lys-Tyr-Tyr-Leu-NH2 (Disulfide bridge:Cys2-Cys17;Cys9-Cys22;Cys16-Cys29)
Sequence Shortening

DCLGWFKSCDPKNDKCCKNYTCSRRDRWCKYYL-NH2 (Disulfide bridge:Cys2-Cys17;Cys9-Cys22;Cys16-Cys29)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Ceratotoxin-2 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ceratotoxin-2880885-98-3CcoTx2 β-TRTX-cm1bCeratotoxin2Ceratotoxin 2CcoTx 2CcoTx-2Sodium ChannelNa channelsNa+ channelsCeratogyrus cornuatusX. laevis oocytesInhibitorinhibitorinhibit

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